Study On The Clinical Characteristics With The Skin Physiology Function In Patients With Acne Of Correlation Analysis In Yunnan Area

Objective Discussion the clinical characteristics and the physiological features of skin in patients with acne in Yunnan area, through evaluating the relationship between the skin barrier damage and the clinical features, to provide guidance prevention and treatment for patients with acne.Methods The clinical data of 330 acne patients in Yunnan area were collected and 130 cases of healthy were selected as control group in this study. The noninvasive skin physiological function tester were used to test the cheek stratum capacitance (CAP), the transepidermal water loss (TEWL)and the skin sebum content of all the subjects. Compared with the healthy subjects and the different age, the different severity of acne patients by rank and inspection, to determine the extent of the damage of the skin barrier and analyze the correlation between the damage of the barrier and the clinical features.Results1. General situation:There were 330 cases of patients with acne, which had 60 were male,270 patients were female; the. average age was(25.78±6.17) years old, the youngerst one was 15 years old,the olderst one was 45 years old.2.The clinical characteristics of patients with acne:(1) Age:according to the United Nations and China on the criteria for the classification of the age,in the 330 cases,there are 189 cases in the youth acne patients,141 cases in the young-middle-aged one, the ratio of two to 1.34:1; (2) Gendenmale 60 cases, female 270 cases, male to female ratio of 0.22:1;(3) Severity.according to China acne treatment guidelines (revised version of 2014), the 330 cases of acne patients were divided into three degrees groups of severity, including:104 cases of mild,119 cases of moderate,107 cases of severe. There were 52 cases of mild,64 cases of moderate, 73 cases of severe in the youth group, and 52 cases of mild,55 cases of moderate,34 cases of severe in the young-middle-aged group. By comparing the two groups, we know that the youth group was more serious than the young-middle-aged group(P< 0.05); (4)The multi factor Logistic regression analysis showed that:the occurrence of acne has a significant positive correlation with sweet diet, spicy diet, stay up late and the use of skin care products, although the correlation between acne and drinking or not is not positive significant, but the regression coefficient is greater than 1, it may increase the incidence of acne.3.Noninvasive physiological function in acne patients:(1) The stratum CAP,the TEWL and the skin sebum content of 330 cases of acne patients were respectively:36.62±13.38、15.64±8.41、102±75, and the healthy control cases were respectively:61.97±11.78、9.04±2.41、40.72±24.06. The comparison shows that the stratum capacitance of acne patients was significantly lower than that of healthy control group,the TEWL and the skin sebum content was significantly higher than the healthy control group(P<0.05);(2) Comparison of the skin physiological functions of different age groups of patients with acne:the stratum CAP,the TEWL and the skin sebum content of the youth group was36.2±13.05、15.3±8.37、116±84.The young-middle-aged group was 37.5±13.59、 16.87±6.04、 90±58, and Compared with the healthy group of corresponding, the stratum capacitance of acne patients were lower,the TEWL and the skin sebum content were higher than the healthy control group. And comparison between the youth group and the young-middle-aged group, there is no significant difference in the stratum CAP and the TEWL, but the skin sebum content of youth group was higher than another group(P<0.05).(3) Comparison of skin physiological function in patients with different degrees of severity of acne:the stratum CAP,the TEWL and the skin sebum content of mild group were:35.9±9.73、15.81±6.42、65.05±19.01;the moderate group were 40.69±10.1、16.93±6.21、103.92±22; the severe group were 36.4±11.27.17.09±6.0、 183±85; compared with the healthy group, the stratum capacitance of acne patients were all lower than the healthy group, the TEWL and the skin sebum content were all higher than another(P<0.05); And comparison between the mild, moderate and severe acne patients, there is no significant difference in the stratum CAP and the TEWL, but the skin sebum content of severe group was higher than the other two and the moderate one was higher than the mild one(P<0.05).In the youth group,the stratum CAP,the TEWL and the skin sebum content of mild group were:36.92±10.92、 16.41±7.19.67.4±10.07;the moderate group were 40.81±10.0、16.46±5.77、 107.74±22.51; the severe group were 36±11.75,16.48±6.31,185±89.5.And compared with the three indicators, there is no significant difference in the stratum CAP and the TEWL, but the skin sebum content of severe group was higher than the other two and the moderate one was higher than the mild one(P<0.05); In the young-middle-aged group,the stratum CAP,the TEWL and the skin sebum content of mild group were:38.08±7.89.15.21±5、62.69±17.76;the moderate group were 40.56±10.29. 17.48±6.70、99.47±20.72; the severe group were 38.01±9.23、18.41±5.11、 187.4±57.43.Compared with the three indicators, there is no significant difference in the stratum CAP, but the TEWL of severe and moderate group were higher than the mild one (P<0.05). The skin sebum content of severe group was higher than the other two and the moderate one was higher than the mild one.4.Correlation between skin physiological function and epidemiological characteristics of acne patients:(l)Age:the youth group which used the skin care was 75.1%,the young-middle-aged group was 88.7%(P<0.05), the youth group which liked the sweet food was 20.1%,the young-middle-aged group was 8.5%(P<0.05); the youth group which liked spicy food was 55.6%,the young-middle-aged group was 40.4%(P<0.05);the youth group which liked stay up late was 50.3%,the young-middle-aged group was 34.8% (P<0.05).(2)Order of severity:the mild of the acne which used the skin care was 84.6%,the moderate of the acne group was 76.4%,the serious acne group was 82.2%(P>0.05); the mild group which liked the sweet food was 16.3%,the moderated group was 16.0%,the serious group was 13.1%(P>0.05); the mild group which liked spicy food was 48.1%,the moderated group was 49.6%,the serious group was 49.5%(P>0.05); the mild group which stayed up late was 46.2%, the moderated group was 43.7%,the serious group was 41.1%(P>0.05).Conclusion 1. The degrees of severity of acne is related to age, which is the severity of acne in youth were more serious than others.2. Proving sweet diet, spicy diet, stay up late and do not use of skin care products habits are the risk factors of acne.3. The stratum capacitance of acne patients was low, the TEWL and the skin sebum content was high, the skin barrier would been damage, and it also related to age and severity.