The Association Between Asthma And Helicobacter Pylori Infection Among Adult Population

Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze,shortness of breath, chest tightness and cough that vary over time and intensity, together with variable expiratory airflow limitation. Recently, the prevalence of asthma is increasing and asthma has become one of the great concern of public health. Therefore,Studies aiming to elucidate the pathogenesis of asthma are needed so as to optimize the strategy in prevention and treatment of asthma.Objective: The effects of Helicobacter pylori(HP) infection on the development of asthma was studied by measuring HP antibodies as well as other asthma related data. The relationships among HP antibody and these parameters were studied correlatively so as to provide evidence for further prevention and treatment of asthma.Methods: Eighty-eight asthma patients(32 males, 56 females) were enrolled from April2014 to April 2015 according to the inclusion criteria and exclusion criteria of the study.Among them, there were 51 acute asthma patients in acute attack stage and 37 patients in remission stage. The average age of these 88 cases was 42±13.33 years old. Meanwhile,forty-three healthy controls(18males, 25females) were recruited whose average age was41±13.15 with no statistically significant difference with asthma group(P>0.05). 2ml blood samples were collected intravenously from every individual of asthma group and control group. The serum level of Hp-Ig G and Ig E were measured using enzyme linked immunosorbent assay(ELISA) and immunoluminometric assay respectively. Then the lung function data, including FEV1, FEV1%, FEV1/FVC, FEF25%, FEF75%, FEF25%-75%, were tested. At last all the results were carefully recorded and SPSS 16.0 was used to analyze the data. The relationship among serum Hp-Ig G level and other asthma markers was studied using linear regression analysis.Results: 1. The Hp-Ig G positive rate of asthma group was 31.8% with significant statistical difference with healthy control, which was 51.2%(P<0.05). 2. The average levelof serum Ig E of asthma group was 143.07±43.84AU/ml, significantly higher than that of healthy controls(P>0.05). Within the asthma group, serum Ig E level of the acute attack subgroup individuals was 171.06±31.86 AU/ml, significantly higher than remission subgroup(104.49±24.40 AU/ml, P<0.05). 3.The lung function data of asthma cases,including FEV1、FEV1%、FEV1/FVC、FEF25%、FEF75%、FEF25%-75%, were lower than control group with significant statistical difference. 4. According to the linear regression analysis result, serum Hp-Ig G was negatively related to serum Ig E level, FEV1, FEV1%, FEV1/FVC,FEF25%, FEF75%, FEF25%-75% with significant statistical difference(P<0.05).Conclusions: 1.The Hp-IgG positive rate of asthma cases is lower than non-asthma cases.2. The average level of serum Ig E of asthma group is higher than healthy controls, the Ig E level of acute attack subgroup individuals is higher than remission subgroup. 3. The lung function data of asthma cases, such as FEV1、FEV1%、FEV1/FVC、FEF25%、FEF75%、FEF25%-75%, are lower than healthy controls. 4.In asthma cases, there is negative relationship between serum Hp-Ig G and lung function data, including FEV1 、 FEV1% 、FEV1/FVC、FEF25%、FEF75%、FEF25%-75%...