| Objective:The aim of this study was to investigate the significance of three kinds of biomarkers combined with MICH score in predicting the prognosis of patients with spontaneous intracerebral hemorrhage(sICH).Method:Clinical data of 119 patients with s ICH were analyzed retrospectively. The serum concentration of GFAP, CRP, Copeptin in patients with sICH were measured on the day of definite diagnosis. The MICH score was calculated, and the mortality of 30 days were followed up. Of the surviving patients were followed up to three months to continue to carry out mRS(modified Rankin Scale) score, the mRS score <3 points is a good prognosis, the mRS score ≥3 points is considered poor prognosis. The relationship between GFAP, CRP, Copeptin level and prognosis was analyzed.Results:1. MICH score of 0, 1, 2, 3, 4, 5 points in patients with sICH 30 d mortality were 0, 9.09%, 14.29%, 41.18%, 53.85%, 81.82%, respectively.2. Compared with survival group and group with good prognosis, the serum levels of GFAP, CRP, and Copeptin were higher in patients who died and with poor prognosis(P<0.05).3. GFAP, CRP, Copeptin and MICH score had statistical significance in predicting prognosis(area under ROC curve was 0.805, 0.719, 0.868 and 0.808 respectively,P<0.05); The area under ROC curve of GFAP, CRP, and Copeptin to predict prognosis together was 0.898(P<0.05). The area under ROC curve was 0.953(P<0.05) when GFAP, CRP, and Copeptin were combined with MICH score, which was higher than related biomarkers or MICH score alone in predicting prognosis.Conclusions: 1. The higher the MICH score, the higher the 30 d mortality in patients with sICH.2.Serum levels of several related biomarkers were higher in death group and group with poor prognosis. GFAP, CRP, and Copeptin have predictive effect for the prognosis with sICH. Several related biomarkers combined with MICH score have important predict value for the pregnosis of patients with s ICH. |
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