| Objective: To observe the kidney and nourishing blood activating blood method in the treatment of kidney Yang deficiency with blood stasis syndrome in the late period of clinical curative effect and explore its action mechanism.Methods:Observation of 60 patients with kidney Yang deficiency with blood stasis syndrome menstruation late, treatment group 30 cases, use of Chinese medicine professor ye qing founded in shandong province for the kidney and activating blood and blood benefit kidney stage treatment; The control group 30 cases, taking less proprietary Chinese medicine capsules, both drug curative effect evaluation after three months. Observe the two groups before and after the first treatment period and clinical symptom scores, serum hormones(FSH, LH, T, PRL, E2) levels, basic body temperature change and use process of any adverse reaction, to observe the results of statistical analysis.Results: Clinical efficacy of the treatment group was 93.3%, control group is 70.0%, comparing the two groups have significant difference(P < 0.05). Accumulated integral aspect of syndromes of traditional Chinese medicine(TCM) and primary symptom integral, the integration of the two groups are also significantly lower before treatment, comparing the two groups have significant difference(P < 0.05). After treatment in patients with serum E2 and FSH compared with before treatment with significant difference(P < 0.05), T, PRL, LH after treatment compared with before treatment there was no significant difference(P > 0.05). The basal body temperature after treatment in both groups was improved, the treatment group after treatment for a period of treatment, the effective rate was 83.30%. Control group effective rate was 56.66%, there is a very significant difference(P < 0.01), the contrast between the two way has a very significant difference(P < 0.01). In this experiment does not appear harmful response.Conclusion:The kidney and nourishing blood and treatment of kidney Yang deficiency with blood stasis syndrome menstruation late has significant clinical efficacy, safety and reliability. Its mechanism may be related to the kidney and nourishing blood huoxue method can rise early follicular E2, FSH levels, adjust endocrine levels in patients with relevant. Tip the kidney and nourishing blood activating blood may treat patients by adjusting the endocrine level and to achieve. |