Study On The Serum Concentration Of PGE₂ And Bradykinin Correlated With The Pain In Knee Osteoarthritis Patients

Objective: Pain is the principal clinical manifestation of degenerative osteoarthritis as well as many other types of osteoarthritis, which affected the survival and life quality of patients seriously at advance stage. The key reason of the pain in knee osteoarthritis patients is pain-induced substance, which secret from inflammatory meditators via cell signal transduction simulated by inflammatory factors. PGE2 and Bradykinin, which represent the main pain-induced substances, play a key role in the mechanism of pain. This study focused on the changes of serum concentration of PGE2 and Bradykinin combined with McGill pain questionnaire at previous-Total Knee Arthroplasty(pre-TKA) and post-TKA periods in Knee Osteoarthritis(KOA) patients, and revealed the effect of TKA in KOA patients.Methods: We collected 30 KOA cases undergoing TKA during Mar 2013 to Dec 2013, and researched the changes of serum concentration of PGE2 and Bradykinin by ELISA methods at pre-TKA and post-TKA periods combined with McGill pain questionnaire, to investigate the effect of TKA in KOA patients.Results: The serum concentration of PGE2 and Bradykinin are statistically meaningful at different periods of pre-TKA and post-TKA(P < 0. 001). The serum concentration of PGE2 and Bradykinin after TKA, which showed lower than that of pre-TKA, are statistically meaningful by t-testing(P <0. 05). The McGill pain questionnaire scores in patients after TKA,which showed lower than that of pre-TKA, are statistically meaningful by t-testing either(P <0. 05).Conclusions: 1. The serum concentration of PGE2 and Bradykinin are correlated with McGill pain scores, indicating that the serum concentration of PGE2 and Bradykinin are correlated with the degree of pain in KOA patients.2. TKA is an effective way of relieving the pain in KOA patients.