The Analysis Of Relationship Between Traditional Chinese Medicine Syndrome Of Primary Liver Cancer With Overall Survival

objective:Filter significative prognosis factors by observing and comparing a variety of different effect factors of prognosis in patients with primary liver cancer in middle and advanced stage,to evaluate the size of the impact on overall survival.Methods:Retrospectively survey HCC patients treated in recent years in XiYuan Hospital of China academy of chines medical sciences.According to inclusion criteria and exelusion criteria, select244eligible cases and21prognostic factors(Gender, age, clinical staging of TCM syndrome types poor appetite, abdominal distension jaundice ascites TNM staging portal tumor emboli liver function whether Child-pugh, classifying the AFP with western medicine treatment of extrahepatic metastasis liver area number of viral hepatitis liver lesion size of intrahepatic lesions history history history of viral hepatitis cirrhosis of the liver cirrhosis of the liver disease).The first in application of Kaplan-Meier(produet-limit method)calculate the total each year Survival rate, analyze survival rate in the single factor analysis, and eompare factors group of each in Log-Rank(log rank test)method of testing, and then apply the COX regression model for multivariate analysis, and serene on the truly meaningful Prognosis of primary liver Caneer, and finally through the prognostic index(Pl)formula(Pl=B1X1+B2X2+B3X3,..., BkXk)to calculate each patient’s prognostic index(P1)value, and eompare the prognostic index(P1)value on the patient survivalrate.Results:Single factor analysis showed that the clinical staging classification of TCM,poor-appetite,abdominal distensionjaundice,ascites,TNM staging,portal vein tumor thrombus, liver Child-Pugh grading,AFP value,with western medicine treatment,extrahepatic metastasis,Intrahepatic lesion,liver lesion size15prognosis factors such as number of intrahepatic lesions was statistically significant(P<0.05), while age and gender weak liver area unwell history factors such as history of viral hepatitis cirrhosis of the liver has no statistical significance(P<0.05).Cox regression model of multi-factor analysis showed that poor-appetite,TNM staging,portal vein tumor thrombus,liver Child-Pugh class,AFP value,with western medicine treatment,liver lesion size Intrahepatic lesion,were statistically significant (P<0.05). Through prognostic index(Pl)equation calculation,prognostic index (PI) value can effectively reflect the prognosis of the patient,the patient’s cumulative survival rate with the increase of prognostic index (PI) value and reduce namely:the greater the value of PI,the worse prognosis and prognostic index (Pl) value is smaller, the better the prognosis.Conclusion:Through single factor and multiple factors analysis, this study found that eight factors were independent risk factors those affect the prognosis of primary liver cancer, according to affect prognosis from the order:the combination of western medicine treatment,Child-Pugh liver function,portal vein tumor thrombus, poor appetite,AFP value,Intrahepatic lesion,live lesion size,TNM stage,which combined western medicine therapy is the only protective factors...