The Correlation Between Breast Cancer And Mammographic Density

Objective: To investigate the differences of mammographic density between the breast cancers and thenormal population, the change rule of mammographic density for women of different ages, and therelationship among factors including mammographic density, age, menopausal states, body mass index(BMI) and breast cancer, whether the factors such as age, menopausal states, body mass index should affecton mammographic density.Methods: The treatment group selected227cases of female breast cancer patients diagnosed bypathological with the full information about mammography, clinical date and pathological date, duringJanuary2011to June2013. The control group selected317cases of healthy women for the purpose ofphysical examination in the hospital, the clinical phys ical examination and various auxiliary examination(mammography, ultrasonography, breast MRI, etc.) without positive found about the breasts during January2013to August. A retrospective analysis of544cases from the first Affiliated Hospital, Medical College ofShihezi University, draw the regions of interest about mammographic density, divided them into4groupsincluding the mammographic density≤25%,25%~50%,51%~75%and>75%, according to the BI-RADSstandard. All subjects were divided into4groups according to age, including≤35,35~45,45~55and≥55years old, and BMI was divided into normal (<24kg.m-2), overweight (24kg.m-2~2kg.m-2) and fat (27kg.m-2). The relationship between breast cancer and mammographic density, age, menopausal status wereanalyzed by nonparametric test, chi-square test, Spearman rank correlation, binary logistic regression,statistic was undertaken.Results:1.The mammographic density of the breast cancers were different from the control group (P=0.012), and when it is higher than51%, the risk of breast cancer would increase. Mammographic densitywas negatively correlated with age and BMI (r=-0.620, r=-0.275, P=0.000), and there are significantdifferences between the premenopausal and postmenopausal (P=0.000).2. The single factor analysisresults showed that age, mammographic density, BMI, menopausal status and weight were related to breastcancer (P <0.05), and different levels of mammographic density had correlation with age, BMI,menopausal status, etc (P=0.000). The breast cancers and control group was different in BMI (P=0.027),which is more significant in postmenopausal state (P=0.002).3. The binary logistic regression resultsshowed that the age, mammographic density and BMI were risk factors for breast cancer. Women less than45had higher probability (P <0.05)to suffer breast cancer, especially, women among35to45years old,who was4.878times than those less than35years (P=0.003). Mammographic density in51%~75%and>75%were more likely to develop into breast cancer than those less than25%. With the BMIincreasing gradually, the risk of breast cancer increased (P <0.05).Conclusion:1.The mammographic density was different between the breast cancers and the control group,and the breast cancers had higher mammographic density than the control group.2. Mammographic density was significantly different in different age, and the younger women has denser density, with the growth ofthe age, the density decreasing gradually, postmenopausal women had lower mammographic density thanpremenopausal, which is influenced by weight and BMI. With BMI increasing, mammographic densitydecreases gradually. Postmenopausal women’s BMI was higher than the premenopausal’.3. The risk ofdeveloping breast cancer would increase, as the mammographic density, BMI gradually rose.Mammographic density should be an indicator in clinical to predict breast cancer risk. The women less than45years, postmenopausal women who were obese, as the age growth, their breast dense area also increased,the probability of breast cancer should rise.4. The mammographic density, age, BMI, menopausal statuswere comprehensively considered, the results reflect a higher state of breast cancer susceptibility. Weshould strengthen the monitor, popularized knowledge of cancer prevention, advocated healthy andgenerous lifestyle.