The Meta-analysis Of The Relationship Between Mammographic Density And Breast Cancer

Objective: To explore the relationship between mammographic density and breast cancer through the Meta analysis.Methods:The MEDLINE, PubMed, Proquest PubMed, ProquestEmbase, ScienceDirect, substitutes Healthline, BMJ Health Intelligence and China journal net medical literature full-text database were used by computer to identify literature published from January2006to December2013without language restricted, that related to both the mammographic density and breast cancer. In addition, we performed other retrieval methods to search for more studies. Two investigators independently select literatures with inclusion criteria and exclusion criteria strictly. And the use Meta-analysis to these literatures with the software ofRevman5.2.Results:A total of5studies that meet the inclusion and exclusion criteria were included. There were4case-control studies and1Meta-analysis. The Meta-analysis include42case-control study which in form of14000cases and226000controls. The4case-control studies were in form of6776cases and14837controls. To Meta analysis into the research of data, the results showed that in breast density is(less than10%as control group),1. when the breast density between10%to25, the merger OR of correlation between breast cancer and breast density is1.42,95%CI (1.29,1.56);2.when the breast density between25%to50%, the merger OR of correlation between breast cancer and breast density is2.17,95%CI (1.99,2.36);3,.when breast density is higher than50%, the merger OR of correlation between breast cancer and breast density is5.25,95%CI(4.76,5.80)Conclusion:The risk of breast cancer was increased by the mammographic density. The probability was5.25times than the mammographic density was lower than10%when the mammographic density is higher than50%. Three groups of the P values was<0.01, and all of the studies were statistical significance. Breast density maybe the independent predictors of breast cancer.