The Impact Of Serum And Follicular Fluid PAI-1by Bushenhuoxue For The Patients Of Polycystic Ovary Syndrome

Objcetive: Observational studies in patients with kidney and blood stasis mechanismof action in vivo expression of PAI-1and Bushenhuoxue party polycystic ovary syndrome.Methods: To select the line in vitro fertilization-embryo transfer (IVF-ET)Polycystic ovary syndrome (PCOS) and60patients with normal women of childbearingage (due to male factor treatment in patients with normal females)30cases,60cases ofPCOS patients and then randomly divided into treatment and control groups. Treatmentgroup were given medicine+Diane-35(cyproterone acetate), the control group weretaking Diane-35to be two cycles. Control group (normal female) without medication.Three patients were in the second period with a long luteal phase pituitary down-regulationprogram, HCG Comparative E2levels in serum and egg retrieval day follicular fluid werecollected using enzyme-linked immunosorbent assay (ELISA) assay which PAI-1levels ofdifferent factors. PCOS patients were recorded before and after treatment of kidney andblood stasis syndrome improve the situation, serum follicle stimulating hormone (FSH),luteinizing hormone (LH), estradiol (E2), testosterone (T) concentrations in serum PAI-afactor and fasting plasma glucose (FPG), fasting insulin (FINS), and insulin resistanceindex (HOMA-IR). Through statistical analysis, numerical changes observed between thethree groups of patients.Results:1After treatment the degree of blood stasis syndrome Kidney improvesignificantly better than the control group (P <0.05), the difference was statisticallysignificant.2treatment group LH, T, FINS, HOMA-IR were significantly lower than thecontrol group (P <0.05), the difference was statistically significant. Compare Top3threegroups patients showed serum PAI-1, PAI-1levels in the blood PCOS groups were significantly higher than the control group (P <0.01). The difference was statisticallysignificant. Blank group COH day serum PAI-1results with menstrual blood PAI-1showedno significant change after treatment PCOS groups (COH day) blood PAI-1pairwisecomparison shows: the treatment group reduced the extent of PAI-1in blood significantlybetter than the control group (P <0.05), the difference was statistically significant. Werecompared among the three groups: control group> treatment group> control group.4egg retrieval day follicular fluid PAI-1pairwise comparison shows: the treatment group/control group follicular fluid PAI-1levels were higher than the control group PAI-1(P<0.001), the difference was statistically significant; treatment and control PAI-1infollicular fluid group compared (P <0.05), the difference was statistically significant.Pairwise comparisons among the three groups were significant differences among the threegroups were compared: control group> treatment group> control group.5Blood PAI-1levels and BMI, FINS, HOMA-IR, follicular fluid PAI-1was significantly positivelycorrelated.Conclusion:1. Fibrinolytic capacity Kidney Blood type PCOS patients comparedwith normal controls declined.2Bushenhuoxue order to effectively improve the systemicsymptoms of PCOS patients with kidney and blood stasis, kidney and blood stasissyndromes mechanism to improve and regulate their blood stasis kidney PCOS patientsfibrinolytic capacity.3Bushenhuoxue side adjustment mechanism PCOS fibrinolyticsystem disorders may regulate endocrine levels and lower insulin levels, insulin resistancerelated.