The Clinical Features Of Nodular Goiter With Thyroid Cancer

Objective:To analyze the clinical features of nodular goiter associated with t-hyroid cancer. Methods:The clinical data of 215 cases of patients with nodular g-oiter associated with thyroid cancer and 401 cases of patients with nodular goiter were retrospectively analyzed. Results:There were statistically significant differenc-es in eight indicators, including total thyroxine (TT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TgAb), nodule volume, internal echo, calcification, i-nternal blood flow, peripheral blood flow, between the case group and the control group(P<0.05). Among patients aged from 20 to 29 years old and those not less than 70 years old, the proportions of nodular goiter associated with thyroid cancer that were higher than the group from 50 to 59 years old(x=3.572、6.982, P>0. 05). In TT4<51. OOng/ml group, the proportion of nodular goiter associated with t-hyroid cancer that was higher than TT4≥141.OOng/ml group(x2=10.000, P=0.00 7). In TSH≥4.20μIU/ml group, the proportion of nodular goiter associated with t-hyroid cancer that was higher than TSH<0.27μIU/ml group and 0.27～4.20μIU/m 1 group(x2=6.040、4.323,P<0.05). In TgAb≥115.00IU/ml group, the proportion of nodular goiter associated with thyroid cancer that was higher than TgAb 0-115. 00 IU/ml group(x2=22.236, P=0.001). Conclusion:Low levels of TT4 and high 1-evels of TSH、TgAb that increased risk of nodular goiter with thyroid cancer. In t-he Doppler ultrasound examination for thyroid, the analysis of the small volume, hypoechoic echo, being with calcification, abundant blood flow nodule in nodular g-oiter patients, they should be suspected as thyroid cancer as soon as possible.