Distribution Of TCM Syndromes Of Diabetic Osteoporosis And The Correlations Between Osteoporosis And Diabetes Mellitus

Object i veTo probe the characteristics of distribution of TCM syndrome of Diabetic Osteoporosis (DOP), and analyze the correlations between osteoporosis and diabetes mellitus, in order to have more effective clinical diagnosis and treatments.MethodsWe collected the clinical data, including general materials, bone mineral density (BMD), biochemical indicators of bone metabolism:β-C-terminal telopeptide of type I collagen (β-Cross Laps), The total N-terminal extension of type I collagen peptide (tPINP) and Human N-MID Osteocalcin (NMID), glycosylated hemoglobin (HBAIc) and four diagnostic materials of TCM from48 eligible patients with simple OP, which formed Group NDM and 32 patients with OP+DM which made up Group DM, were enrolled for our study. Then We analyzed the distribution pattern of TCM syndromes of OP and the specialty of TCM syndromes of OP+DM。The acquired data were analyzed statistically by using SPSS19.0.Results1. OP was more common in the women, The comparison of the sex between the two groups showed no statistics meaning (P=0.079>0.05);2. OP was more common in the elderly, the average age of Group NDM was 79.35±6.20 years old and the average age of Group DM was80.50±6.14 years old. The comparison of the average ages between the two groups showed no statistics meaning.3. The average HbAlc of Group NDM was 5.84±0.54% and that of Group DM was 6.29±0.6% The comparison of the average HbAlc between the two groups showed statistical significance (P=0.002<0.01)。4. The average BMD in femoral neck of Group NDM was -3.35±0.47g/cm2 and that of Group DM was-3.62±0.60g/cm2 The comparison of the average BMD between the two groups showed statistical significance (P=0.027)。But Pearson correlation analysis between HbAlc and BMD showed that there is no significant correlation between them (r=-0.120, p= 0.290).5. The average NMID of Group NDM was 26.19±7.20ng/ml and that of Group DM was 22.94±6. Ong/ml. The comparison of the average NMID between the two groups showed statistical significance (p=0.032).Pearson correlation analysis between HbAlc and NMID showed that there is significant negative correlation between them (r=-0.266, p=0.017).6. The average β-Cross Laps of Group NDM was 0.67±0.36ng/ml and that of Group DM was 0.87±0.40ng/ml. The comparison of the average β-Cross Laps between the two groups showed statistical significance(P=0.021＜0.05). Pearson correlation analysis between HbAlc and β-Cross Laps showed that there is significant positive correlation between them(P=0.008<0.01,r=0.295).7. The average tPINP of Group NDM was 55.70±28.67ng/ml and that of Group DM was 42.69±23.05ng/ml. The comparison of the average BMD between the two groups showed statistical significance (p=0.028<0.05). Pearson correlation analysis between HbAlc and tPINP showed that there is significant negative correlation between them (r=-0.241, p=0.031).8. In NDM Group, the patients with kidney deficiency type had the highest proportion (45.8%), and then was Qi stagnation and blood stasis type (29.2%), and then Spleen kidney yang deficiency type (25%);and in DM Group patients of kidney deficiency type also had the highest proportion (59.3%),and then was Qi stagnation and blood stasis type (31.1%), and then was Spleen kidney yang deficiency type (9.4%).The comparisons of TCM syndrome distributions between the two groups is that kidney deficiency type and Qi stagnation and blood stasis type between the two groups showed no statistics meaning (P>0.05). Spleen kidney yang deficiency type between the two groups showed statistical significance (P<0.05)9、We summarized the TCM syndromes elements in these patients of OP, and found that there were 6 syndromes elements:spleen, kidney, yin-deficiency, yang-deficiency, blood stasis, dampness. The syndrome elements of disease location was:kidney, spleen. The syndrome elements of disease increased yin-deficiency, yang-deficiency, blood stasis, dampness.10. On the syndrome elements of disease location:There were 81.3% of patients in NDM Group and 90.6% of patients in DM Group with kidney syndrome, the two groups showed no significant difference. And There were 35.4% patients in NDM Group and 15.6% patients in DM Group with spleen syndrome, showing statistically significant (P=0.044<0.05).11. On syndrome elements of disease:47.25% of OP patients have symptoms of blood stasis. There are 41.7% patients in NDM group and 56.3% in DM group, there are no significant difference between the two groups.31.25% of OP patients have symptoms of dampness. There are 41.7% patients in NDM group and 15.6% in DM group, he two groups showed statistical significance. (p=0.012<0.05)There were 33.3% patients in NDM group and 78.1% in DM group with yin-deficiency, showing statistically significant (P=0.000<0.05).And there were 45.8% patients in NDM group and 21.9% in DM group with yang-deficiency, also showing statistically significant (P=0.025<0.05)ConclusionIn this study, clinical research shows:1.There is significant positive correlation between HbAlc and β-Cross Laps.2. There is significant negative correlation between HbAlc and NMID, tPINP.3. The results indicate that control the blood sugar level continued and timely, help control the progression of the OP.4. The results shows that liver and kidney deficiency syndrome is the most important type of OP, and the patients of OP complicated with DM has less proportion in the spleen deficiency syndrome distribution.5. The features of OP complicated with DM on TCM syndrome elements:① Kidney deficiency and blood stasis are the most important TCM syndrome elements of OP complicated with DM② The cases of OP complicated with DM have less proportion in insufficiency of the spleen,dampness and yang-deficiency;and have more proportion in yin-deficiency.