Effectiveness Of BiLevel Positive Airway Pressure Non-invasive Ventilation In AECOPD Complicated With Type â…¡ Respiratory Failure

Objective:Explore the clinical efficacy of BiLevel Positive Airway Pressure non-invasive Ventilation in AECOPD (the acute exacerbation of chronic obstructive pulmonary disease) Complicated with Typeâ…¡Respiratory Failure. Methods:50 cases of AECOPD complicated with Typeâ…¡Respiratory Failure were randomly divided into two groups. The treatment group (25 cases) use conventional therapy and BiPAP non-invasive Ventilation treatment; The control group (25 cases) use conventional therapy and Continuous oxygen by nasal tube or mask, while giving the appropriate respiratory stimulant treatment. Symptoms and Vital signs and arterial blood gas parameters were compared after 3d treatment. Results:The treatment group after 3d treatment compared with before treatment:The symptoms of patients improved significantly; RR (t=40.47, P <0.05), HR(t=40.32,p<0.05), SaO2 (t=-27.83, P<0.05), PH (t=-11.62, P<0.05), PaO2 (t=-20.71, P<0.05), PaCO2 (t=23.81, P<0.05), differences were statistically significant. The control group after 3d treatment compared with before treatment:The symptoms of patients improved; RR (t=28.52, P<0.05), HR(t=28.84, P<0.05), SaO2 (t=-19.43,p<0.05),PH (t=-11.07,P<0.05), PaO2 (t=-17.59,P<0.05), PaCO2 (t= 17.10, P<0.05), differences were statistically significant. After 3d treatment, the treatment group compared with control group:The symptoms of patients improved significantly; SaO2 (t= 12.45, P<0.05), PaO2 (t=5.85, P<0.05), PaCO2 (t=-11.06, P <0.05), differences were statistically significant. For non-normality distribution of RR,HR and PH, so use the non-parametric test, RR (Z=-5.88, P<<0.05), HR (Z=-5.85, P <0.05), PH (Z=-5.22, P<0.05), differences were statistically significant. Symptoms and vital signs and arterial blood gas parameters were significantly improved after treatment in treatment group by BiPAP non-invasive ventilation(P<0.05).There was significantly more improvement in treatment group than in control group. Conclusion: The early use of BiPAP non-invasive ventilation in AECOPD complicated with type II respiratory failure can rapidly improve clinical symptoms, and facilitate recovery from respiratory failure compare with conventional medical therapy, and easy to use.