TCMISS-based Analysis On The Regularity Of Ancient TCM Prescriptions For Chronic Renal Failure

Objective:To explore composing principles of prescriptions for chronic renal failure(CRF) recorded on the Encyclopedia of Traditional Chinese Medicines based on the traditional Chinese medicine inheritance support system (TCMISS).Methods:Prescriptions for chronic renal failure recorded on the Encyclopedia of Traditional Chinese Medicines were entered into the TCMISS. Composing principles of these prescriptions were analyzed by TCMISS-integrated unsupervised data mining algorithms (including Improved Mutual Information, Complex Systems Entropy Clustering, and Unsupervised Entropy Hierarchical Clustering).Results:Eighteen core herbal combinations and 9 new prescriptions were evolved and obtained by analyzing 221 selected prescriptions for chronic renal failure and determining frequencies of occurrence of Chinese medicinal herbs in these prescriptions.Coneclusion:Syndrome differentiation and treatment of chronic renal failure based on ancient documents research and analysis of prescriptions. We got the common understanding of the prescription regulation that treat the CRF, and features, such as the common understanding of the treatments and features of the chronic kidney failure. The study also can be referred as a reference to inherit and carry forward the traditional Chinese medicine academic experiences.