Correlation Of Ductus Venosus Dopler Velocimetric Parameters With Gestation Period In Fetus Venosus Between11and13⁺⁶ Weeks Of Gestation

Objective To investigate the correlation of ductus venosus (DV)Doppler velocimetric parameters with gestation period in women at11to13+6weeks gestation in normal pregnancies.Methods A prospective observational study was performed on532pregnant women who underwent ultrasound examination during11to13+6weeks of gestation in the department of obstetrics of the First AffiliatedHospital of Chongqing Medical University from October2012to March2013. The following variables of the ductus venosus were measured: peakvelocity during ventricular systole (S-wave), peak velocity duringventricular diastole (D-wave), the lowest forward velocity during atrialcontraction (A-wave), time-average maximum velocity (TAMXV),pulsatility index (PI), preload index (PLI), and the ratio of maximumpeak systolic velocity during ventricular systole to end-diastolic velocityduring atrial contraction (S/A). Pregnant outcomes were followed up. Finally a total of296normal pregnancies out of532pregnant women wereanalyzed.Results (1) There were significant increase for the S–wave(r=0.237,P=0.000), the D–wave(r=0.251, P=0.000), the A–wave(r=0.217, P=0.000), the TAMXV(r=0.272, P=0.000), and significant decrease for thePI(r=-0.159, P=0.006) with the advancing gestational age in the groupwith normal outcomes. While, PLI （r=-0.096，P=0.098）and S/A（r=-0.089，P=0.128）had no significant change during gestational age.(2) The curve equation of ductus venosus Doppler velocimetricparameters with gestation age were: the S-wave=2.685（gestational age）+3.248; the D-wave=2.367（gestational age）+1.408; the A-wave=1.150（gestational age）-3.110; the TAMXV=2.434（gestational age）-2.584;PI=-0.021（gestational age）+1.189; PLI=-0.006（gestational age）+0.770;S/A=-0.010（gestational age）+3.727.Conclusion The S–wave, D-wave, A-wave, and TAMXV velocity areincreased, while PI is decreased in ductus venosus indexes along withgestational age.