The Relationship Between Functional Dyspepsia And Mast Cell, Plasma Motilin

ObjectivesBy comparing the number of mucosal mast cells, plasma motilin levels and changes in functional dyspepsia patients and healthy volunteers, our aim is trying to explore the role of the mast cells, motilin in the pathogenesis of functional dyspepsia.MethodsPatients who treated in Digestive Center and clinical department of Fujian Provincial Hospital from September2013to January2014as the research object of this thesis.60patients who fit functional dyspepsia Rome Ⅲ diagnostic criteria were selected as the experimental group (PDS subgroup+EPS subgroup). There were28healthy volunteers who were selected as control group to make a comparison. This research studied the correlation variables including the number of mucosal mast cell, plasma motilin (after fasting and drinking warm water30minutes) and gastric emptying T1/2. By testing and statistical analysis, the objectives to study the role of these variables in the pathogenesis of functional dyspepsia.ResultsThe results showed that the number of mast cells in the FD group was significantly greater than the control group. And there is a statistically significant difference (P <0.05); the number of mast cells in the EPS subgroup showed no significant difference than the PDS subgroup (P>0.05); After drinking warm water (37°) could stimulate the release of motilin; the level of motilin in the FD group was lower than the control group(P <0.05); the elevating level of motilin in the FD group after drinking warm water was less significant than the control group (P <0.05); the level of motilin in the PDS subgroup was lower than the EPS subgroup and the control group(P <0.05); the elevating level of motilin in the PDS subgroup after drinking warm water were less significant than the EPS subgroup and control group (P <0.05). The level of motilin in the EPS subgroups before and after drinking warm water showed no significant difference than control group (P>0.05).Conclusions1．The number of mucosal mast cells were significantly increased in patients with functional dyspepsia by comparing with the control group. The result was of statistically significance, which showed that MC may play a role in the pathogenesis of FD.2． The level of plasma motilin was lower in patients (PDS subgroup) with functional dyspepsia, which may be one of factors involved in the incidence of FD and produced corresponding symptoms.