Study Of Gastric Emptying And Treatment In Different Subtypes Of Functional Dyspepsia

Objective To study the differences in clinical characteristics of patients with different subtypes of functional dyspepsia,and to explore therapy of functional dyspepsia.Methods From December 2021 to October 2022,Seventy patients with functional dyspepsia admitted to our hospital were included.According to Rome IV diagnostic criteria,patients were divided into postprandial distress syndrome(PDS)(25 cases),epigastric pain syndrome(EPS)(21 cases),and PDS+EPS(24 cases).Social demographic data(including gender,age,education level,smoking and drinking history)were collected in the form of a questionnaire.Zung Anxiety and Depression Scale was used to evaluate their psychological status.Radionuclide imaging was used to evaluate gastric emptying.Urea breath test was used to evaluate Hp infection.Liquid nutritional dietary load test was used to evaluate visceral hypersensitivity.And the differences of the above data among different subtypes were compared.The above patients were randomly divided into two groups: one group received empirical treatment(35 cases)and the other group received etiology-based treatment(35cases).To compare whether there are differences in the two groups.Results 1.There was no statistical significance in age,gender,education level,smoking and drinking among the three groups(PDS,EPS and PDS+EPS),P > 0.05.For anxiety,PDS compared with EPS and PDS+EPS,the difference was no statistically significant,P > 0.05.The difference between EPS and PDS+EPS was statistically significant,P < 0.05,and the proportion of anxiety in the PDS+EPS was higher than that in the EPS.For depression,PDS compared with EPS and PDS+EPS,the difference was statistically significant,P < 0.05,and the proportion of depression in the PDS+EPS and EPS were higher than that in the PDS.There was no statistical significance between EPS and PDS+EPS,P > 0.05.2.There was no significant difference in Hp infection among the three groups,P >0.05.For gastric emptying,compared PDS group with EPS group,the difference was statistically significant,P < 0.05,and the proportion of delayed gastric emptying in PDS group was higher than that in EPS group.There was no statistically significant between PDS group and PDS+EPS group,P > 0.05.There was no statistical significance between EPS group and PDS+EPS group,P > 0.05.For visceral hypersensitivity,PDS compared with EPS and PDS+EPS,the difference was statistically significant,P < 0.05,and the proportion of visceral hypersensitivity in the PDS+EPS and EPS were higher than that in the PDS.There was no statistical significance between EPS and PDS+EPS,P > 0.05.3.The difference of curative effect between the two groups of different treatment methods was statistically significant,P < 0.05.The etiological treatment is better than that of traditional empirical therapy.Conclusion 1.There was no statistical significance in age,gender,education level,smoking history and drinking history among patients with different subtypes of FD.The PDS+EPS had more anxiety than the EPS,and the PDS group had less depression than the other two subtypes.2.There was no statistical significance in Hp infection among patients with different subtypes of FD.The proportion of delayed gastric emptying in the PDS group was higher than that in the EPS group.The proportion of high visceral sensitivity in EPS and PDS+EPS was higher than that in PDS patients3.For FD,the etiological treatment is better than that of empirical therapy.