| Diabetes mellitus is one of clinical common endocrine system disease, serious threat to human life and health. According to the WHO data show that in1995diabetic patients around the world, about125million people, about135million people by1998, and forecast according to the data, by2025, this figure will exceed300million mark even. Diabetes and its complications after heart cerebrovascular disease has become one of high morbidity and high lethal disease.In recent years, with the rapid economic development of our country, the people’s living standards improve, as well as the pace of life, the life pressure, the change of lifestyle, the incidence of diabetes has increased obviously, which brought huge burden for health care. Literature and clinical data indicate that most patients with type Ⅱ diabetes is associated with lipid metabolism disorders. Type Ⅱ diabetes lipid metabolism disorder is likely to be the important condition of large vascular and microvascular complications, it is the leading cause of severe type Ⅱ diabetes of the main causes of mortality.Chinese medicine treatment of type2diabetes and lipid metabolism disorders have experienced, and the foundation of Chinese medicine treatment is diagnosis and treatment of disease, the study of type2diabetes and lipid metabolism disorder syndromes distribution of clinical medicine for the prevention and treatment of the disease is of great significanceFrom the treatment in terms of traditional herbal treatment of type2diabetes and lipid metabolism disorders has many advantages, such as multi-target, multi-channel, side effects caused by long-term use smaller and so on. South African traditional herbal Quassia amara in the treatment of diabetes has been some research and clinical application of a long time, but the intervention of lipid metabolism in diabetic needs to be further explored in the study, so the study of South African traditional herbal Quassia amara diabetes intervention and mechanism of lipid metabolism were studied. In this study, animal experiments is the way of the high fat diet of SD rats made diabetic by intraperitoneal injection of STZ lipid metabolism model for therapeutic intervention Quassia amara solution, the results show a certain degree of blood glucose and lipids, and Based on this mechanism were studiedThe study is divided into three parts: The first part is a review section, through literature, and the progress of modern medicine, traditional Chinese medicine research in type2diabetes and lipid metabolism disorders were reviewed. A major review from TCM etiology and pathogenesis, syndrome differentiation and treatment of TCM summarized the research progress of type2diabetes and lipid metabolism disorders; Summary II clinical features, pathogenesis, hazards, and other aspects of the treatment and prognosis of type2diabetes fat reviewed Advances in medical research of metabolic disordersThe second part is the part of the clinical study. Objective:To analyze lipid metabolism in type2diabetes patients with syndromes distribution Methods:Retrospective analysis of clinical data on125type2diabetic patients with lipid metabolism disorders Syndrome statistics. Results:(1) lipid metabolism in type2diabetes patients with syndromes distributed mainly Qiyinliangxu context stasis, Qi blood stasis, Qi and Yin deficiency and blood stasis, which in particular in the context of stasis and Qiyinliangxu Qiyinl iangxu bleeding resistance based.(2)1ipid metabol ism in type2diabetes patients to determine the distribution of TCM mainly deficiency, qi, blood stasis, phlegm, especially Yin, Qi, stasis.(3) Lipid metabolism in type2diabetes patients with blood yin and yang dialectic distribution of qi and yin mainly composite distribution concentrated in Yin Deficiency Syndromes (pairwise composite) and Yin deficiency and blood stasis (three three composite) and the remaining card designate a smaller proportion.The third part is the drug experiment research. Objective:To study the therapeutic effect Quassia amara and mechanism of lipid metabolism in diabetes aspects. Methods:SD rats were fed high-fat diet by intraperitoneal injection of STZ diabetic rats made, divided into model group, pioglitazone group and the experimental group were given distilled water piogl i tazone and Quassia amara gavage treatment, and compare the normal group. Record the amount of drinking water and eating rats in each group every day, every week experiment conducted OGTT.6weeks after, take blood, skeletal muscle, liver, blood biochemical parameters were measured, weighed liver and skeletal muscle and liver immunohistochemistry and PCR assays to study Quassia amara on lipid metabolism in diabetic rats by statistical analysis therapeutic effect and mechanism of action. Results:Diabetes lipidmetabolism in rats after Quassia amara treatment weight increased compared with DM rats, blood glucose, liver index and TG, TC, LDL are reduced, indicating Quassia amara on diabetes and lipid metabolism disorders have certain treatment, it can regulate blood glucose levels in rats, and dyslipidemia can improve the situation in rats. In this experiment, immunohistochemistry showed skeletal muscle and liver tissue in rats, AMPK a, PPAR y compared with DM group increased, while the PCR also showed that rat skeletal muscle AMPKα, gene expression of PPARγ increased compared with DM group the difference was statistically significant, indicating that Quassia amara lipidmetabolism in diabetic hypoglycemic certain lipid-lowering effects, the therapeutic effect is by increasing the expression of type2diabetes in rat skeletal muscle and liver tissue AMPKα and PPARγ mRNA to achieve of... |
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