The Expression Of FKBP51Has A Notable Difference Between Proliferative Phase And Secretory Phase Of Endometrium

OBJECTIVES:A receptive endometrium and a blastocyst of well development are the two decisive factors of the formation of pregnancy. The failure of implantation that leads to a decrease of uterine receptivity is the most common reason of the infertility with patients who have normal ovulations. There exist varies of factors in the process of many kinds of female diseases that can lead to the decrease of uterine receptivity and these factors interact and eventually cause a low pregnant rate among patients. Therefore, finding out the mechanisms of these negative effects and the relationships between factors and the receptivity has great significances upon clinical remedies aiming at the improvement of reproductive ability. FK506binding protein51(FKBP51) has been demonstrated as a key regulator of sex hormones. Sex hormones can regulate the expression level of FKBP51, and in turn the protein, as an important part of the steroid hormone receptor complex, regulates the extent of the hormone affections in various tissues and organs. The aim of this study was to investigate whether the waving levels of sex hormones could result in a remarkable change of the expression of FKBP51in endometrium, with the transformation of endometrium from the proliferative phase to the secretory phase.METHODS:80specimens of endometrium had been collected to compose tissue microarrays. Every point of tissue were confirmed of its pathological diagnosis and staging. The expression of FKBP51had been detected by immunohistochemistry techniques. And statistics analysis of expression level between proliferative phase and secretory phase by Independent-Samples T test in SPPS v19.0were performed.RESULTS:The expression level of FKBP51has a significant difference in endometrial tissue during the menstrual cycle, and level of secretory phase is notably higher than that of proliferative phase (P<0.001). CONCLUSIONS:With the transformation from the proliferative phase to the secretory phase, estrones and androgens down-regulate their levels while the progesterone has an up-regulation course. In this process, the FKBP51expresses increasingly in the endometrium...