Chinese Medicine Internal And External Treatment Of Venous Leg Ulcer Treatment Efficacy Of Clinical Studies

Objective: Venous Leg Ulceration（VLU）is one of the complications oflower extremity venous reflux and reflux disorder of severe and refractorydisease.It is a common and frequently-occurring disease in clinical, withprotraction and recurrent features. Population incidence rate of0.3%to2.0%,and increased gradually with the growth of the age and the incidence of adisease, seriously affects patients’ daily work and life, has aroused people’sattention, is one of the more intractable diseases clinically. The current clinicaltreatment of venous ulcers, there is no ideal solution, western medicine isgiven priority to with surgical therapy, but the wound is larger, expensive, andpart of postoperative recurrence, the long-term curative effect is not exact.Chinese medicine treatment of this disease has a long history, highlighting theeffect, but the local foreign rule-based medicine, the combination of a varietyof therapy needs further study. This paper uses a variety of treatment methodsin combination, internal and external integration, tackling the problem, andhighlights the role of medicine in the treatment of oral and topical venousulcers, will open new ideas treatment of venous ulcers, and to provide areliable basis for improving the clinical cure rate.Methods: This topic research the cases from the hebei province hospitalof Chinese and western medicine combined with surgery, diagnosis ofsuperficial vein of lower limb varicose ulcer of patients in120cases.120patients with superficial vein of lower limb varicose ulcer patients randomlydivided into4groups completely:1Traditional Chinese medicine oral and external treatment group: Theuse of traditional Chinese medicine oral and external treatment, combinedwith elastic bandage, and be of Danhong injection40ml+0.9%NS250mlivgtt, once a day, continuous infusion for two weeks, a month for a course. 2Traditional Chinese medicine external treatment group: The externalapplication of Chinese medicine treatment, combined with elastic bandage,and be of Danhong injection40ml+0.9%NS250ml ivgtt, once a day,continuous infusion for two weeks, a month for a course.3Traditional Chinese medicine oral group: The oral medicine, Leif Nurgauze dressing combined with elastic bandage, and be of Danhong injection40ml+0.9%NS250ml ivgtt, once a day, continuous infusion for two weeks,a month for a course.4Control group: The Leif Nur gauze dressing combined with elasticbandage, and be of Danhong injection40ml+0.9%NS250ml ivgtt, once aday, continuous infusion for two weeks, a month for a course.To observe:1After a period of treatment, To observe the changes of patients withulcer area;2After a period of treatment, Observe the patient’s general condition,such as the degree of pain, ulcer surface color, wound drainage quantity,newborn granulation tissue, such as change, integral to statistics;3After a period of treatment, statistics the ulcer healing rate of thepatients;4After a period of treatment, observe the charge of Venous refill Time,(VRT) measured with photo plethsmography (PPG);The safety evaluates index sign: observe routine blood, routine urine,routine shit, liver function, kidney function, APTT, PT,ECG, and so onbefore and after treatment.Results:1Comparison of ulcer area: After a period of treatment, throughexamination, Traditional Chinese medicine oral and external treatment group,Traditional Chinese medicine external treatment group, Traditional Chinesemedicine oral group and control group, the four groups of ulcer area beforeand after the treatment itself compared with statistical significance(P<0.05).Traditional Chinese medicine external treatment group and Traditional Chinese medicine oral group has no statistical significance. Anyother ulcer area of comparative differences between the two groups havestatistical significance(P<0.05). Multiple comparisons showed the ulcer areaof Traditional Chinese medicine oral and external treatment group decreasedmost, Traditional Chinese medicine external treatment group and TraditionalChinese medicine oral group followed by group, the control group decreasedat least.2Comparison of Chinese medicine symptom: After treatment, theeffective rate of Traditional Chinese medicine oral and external treatmentgroup, Traditional Chinese medicine external treatment group, TraditionalChinese medicine oral group and control group are100%,86.67%,83.33%and66.67%. Through examination,Traditional Chinese medicine externaltreatment group and Traditional Chinese medicine oral group has no statisticalsignificance. Any other effective rate of comparative differences between thetwo groups have statistical significance(P<0.05).Multiple comparisonsshowed the Curative effect of Traditional Chinese medicine oral and externaltreatment group is best. Traditional Chinese medicine external treatment groupand Traditional Chinese medicine oral group followed by group. The Curativeeffect of control group is poorer.3Comparison of the ulcer healing rate: After treatment, the ulcer healingrate of Traditional Chinese medicine oral and external treatment group,Traditional Chinese medicine external treatment group, Traditional Chinesemedicine oral group and control group are90.00%,66.67%,63.33%and46.67%.Through examination,Traditional Chinese medicine external treatmentgroup and Traditional Chinese medicine oral group has no statisticalsignificance. Any other ulcer healing rate of comparative differences betweenthe two groups have statistical significance(P<0.05). and we can think that theulcer healing rate of three groups are different. The ulcer healing rate ofChinese Herbs and external washing Group and Medicine outside washingGroup better than Control group. Multiple comparisons showed the ulcerhealing rate of Traditional Chinese medicine oral and external treatment group is highest. Traditional Chinese medicine external treatment group andTraditional Chinese medicine oral group followed by group. The ulcer healingrate of control group is poorer.4Comparison of VRT: After a period of treatment, through examination,Traditional Chinese medicine oral and external treatment group, TraditionalChinese medicine external treatment group, Traditional Chinese medicine oralgroup and control group, the four groups of Venous refill time before and afterthe treatment itself compared with statistical significance (P<0.05).TraditionalChinese medicine external treatment group and Traditional Chinese medicineoral group has no statistical significance. Any other Venous refill Time ofcomparative differences between the two groups have statistical significance(P<0.05). Multiple comparisons showed the Venous refill Time of TraditionalChinese medicine oral and external treatment group Increased the most,Traditional Chinese medicine external treatment group and TraditionalChinese medicine oral group followed by group, the control group Increasedthe least.5Safety observation: There is no significant change of the four groups byobserving routine blood, routine urine, routine shit, liver function, kidneyfunction, APTT,PT,ECG and so on after treatment(P>0.05). Four sets allhave no obvious poisonous side effect.Conclusion: Applications from Chinese medicine internal and externaltreatment in combination with the conventional method in treatment of lowerlimb venous ulcer in improving patients’ symptoms, reduce the ulcer area ofcurative effect is significant, the total effective rate and ulcer healing rate issuperior to conventional control, illustrate the obvious advantages of Chinesemedicine in treatment of lower limb vein ulcer can obviously shorten the ulcerhealing time, accelerate wound healing, and internal and external combination,severely, is safe and effective, and can improve the venous refill time, improvevenous valve function.