The Correlation Study Between BNP Level And Cardiac Insufficiency And Degree Of Coronary Artery Lesions In Coronary Heart Disease Patients

Background: Coronary heart disease refers to coronary atherosclerosis that causesnewspeak stenosis or obstruction, or (and) myocardial necrosis caused by coronaryartery functional change (spasm). Acute coronary syndrome (ACS) is one of the risktypes of coronary heart disease (CHD), which includes unstable angina and non STsegment elevation myocardial infarction and ST-elevation myocardial infarction.The BNP is mainly stored in ventricular muscle. The production of BNP changes,when the ventricular pressure increases. Its physiological role is to dilate blood vessels,increase sodium, against the renin-angiotensin water sodium retention effect. In1981De-BOLD and others discovered a diuretic natriuretic, which substances in rat hearttissue. In1984this kind of peptide hormone is named as atrial natriuretic peptide(ANP). Brain natriuretic peptide was first discovered from pigs in1988，called the"heart hormone" and produced in the ventricular muscle. The increased pressure ofventricular room wall causes a brief BNP increase. But if the Assyrian stimulus existsfor a long time, the BNP gene transcription would be raised in the mRNA expressionand continued to rise in the blood.Objective: Research the correlation between BNP level and cardiac insufficiencyand degree of coronary artery lesions in coronary heart disease patients.Method: Choose the patients who stayed in cardiology in the first Affiliated Hospital ofDalian Medical University from September to December because of chest pain in2012.All the patients completed Doppler echocardiography, parallel coronaryangiography and BNP examination in24hours.The patients whose level of LVEF is normal were divided into two groupsaccording to the level of BNP. Age, gender, renal function and so on is compared intwo groups. Patients whose level of LVEF is less than50%were divided two groups according to the level of BNP. Logistic regression analysis was made to make surewhich factors have a larger impact analysis on BNP difference.Result: On the analysis of two groups with normal left ventricular ejection fraction(LVEF>50%),wheather involving the left main coronary artery and the left anteriordescending artery proximal entered the regression model. The B values were1.942and2.21. On the analysis of two groups with less left ventricular ejection fraction(LVEF<50%),the left ventricular end-diastolic diameter, involving the left ventricularejection fraction, involving the left anterior descending artery and involving theproximal left anterior descending finally entered the regression model,the B valueswere24.51,109.53,10.78,-18.64. Whether involving the anterior descending BNPhave a greater effect than others. And the number of coronary artery lesion, whetherinvolving the left main, whether there is occlusion had no significant relationship instatistics.Conclusion： Whether involving the left anterior descending artery and proximalleft anterior descending have a great effect on BNP in patients who have coronary heartdisease patients with heart failure,...