Clinical Study On The Application Of Using Percutaneous Radiofrequency Ablation Treatment Of Metastatic Bone Tumors

Objective:To probe deeply into the feasibility,safety and effectiveness of treating metastatic bone tumor with radiofrequency ablation (RFA),provides an alternative operation type for the minimally invasive therapy of metastatic bone tumor.Methods:16cases of metastatic bone tumors (A total of34metastases) undergoing radiofrequency catheter ablation in the First Affiliated Hospital of Kunming Medical University from February2011to March2013were analyzed retrospectively. Of16cases of14cases of vertebral metastasis, involvement for30vertebral bodies,19thoracic spine, lumbar spine9,2sacral vertebra. The rest of the sternum and the right side of the multiple frame transfer in1case, on the right side of the shoulder blade transfer in1case. All patients were in DSA guiding RFA treatment, also including13cases of thoracic and lumbar vertebral metastatic tumor patients after RFA suffer vertebral plasty (percutaneous vertebroplasty, PVP). Radiofrequency ablation parameters setting of4to6minutes, treatment temperature about95d±5℃, radiofrequency electrode is effective treatment of1.5cm-2.0cm in diameter. All electrodes were inserted into the tumor nests center accurately, adjust the Angle of electrode for irregular shape tumor lesions and multiple ablations. The postoperative follow-up was6to12months,, mean follow-up of8.4months, estimating, the preoperative and postoperative pains by Visual Analogue Scale (VAS), the dosage of narcotic analgesics, and estimating the quality of life of patients by EORTCQLQ-C30(V3.0)(European Organization for Research and Treatment, EORTC), meanwhile, doing with the statistical analyses by Paired T-test based on SPSS11.5.Results:All the operations were successfully completed. After followed up to6months all survived, intraoperative and postoperative follow-up does not appear obvious complications.the pain rating index of VAS(visual analogue scale) declined to some extent within24hours, declined in evidence with3days,and without relapses in the next week, nor in the next month,2months,3months or6months, and the differences had statistical significance(P<0.01); And the obvious differences between preoperative VAS and postoperative also had statistical significance(P<0.01), statistically significant, suggests that postoperative pain in patients with a preoperative obviously improved, RFA treatment of metastatic bone tumors has definite clinical effect.Including16cases reduced the dosages of anodyne; So did the domains such as somatic function, emotional function, general health condition, pains, insomnia, between preoperative and postoperative4weeks also had statistical significance(P<0.05). On all accounts, RFA can help ease the pains, insomnia, depression and other symptoms, improve the health condition and somatic function effectively, and so does the quality of life suffered from metastatic bone tumor.Conclusion:First, Radiofrequency ablation is available for the treatment of metastatic bone tumors because of its has superiority of little trauma,feasibility,safely, affectivity, and is worthy to be popularized in operation. Second, the treatment of metastatic bone tumors by RFA can help ease the pains and other symptoms in evidence, Control the condition so striking so to achieve high Clinical Performance Indicators, and evidently improved the quality of life to the patients. Third, vertebral metastatic tumor patients RFA with PVP therapy can effectively prevent vertebral compression fracture and paraplegia patients, pain relief, and other non bearing metastatic bone tumors RFA therapy alone can achieve the purpose of pain relief.