Effect Of Flurbiprofen Axetil On Acute Pain In Patients With Fracture Of A Variety Of Inflammatory Mediators And Pain Score

Objective To observe the effect of flurbiprofen axetil on plasma prostaglandinE₂,5-HT, bradykinin, three kinds of inflammatory mediators and pain score before andafter fracture patients with acute pain medication.Methods Fracture cause in patients with acute pain in hospital as the research object,a total of30, take the intravenous drip of nonsteroidal anti-inflammatory drugs andanalgesic efficacy of flurbiprofen axetil injection for analgesia. Respectively beforeand after treatment by simplifying the pain degree of patients with McGill pain scoreevaluation, determination of plasma prostaglandin E₂,5-HT, bradykinin levels.Results patients before treatment30min prostaglandinE₂,5-HT, bradykininconcentration and the MPQ score was significantly higher than that after treatment2h,6h （P <0.05）.After6h plasma prostaglandin E₂, bradykinin concentration higherthan after administration of2h （P<0.05）. After administration of6h McGill painscore higher than2h after the treatment.Conclusion Flurbiprofen axetilcan inhibit the fracture caused by acute pain inpatients with prostaglandinE₂,5-HT, bradykinin concentration in plasma and caneffectively reduce the pain of patients.Its effect sustained for up to6hours, theanalgesic effect gradually weakened over time, six hours after the medication is no medication2hours after a significant effect.