Observation On Analgesic Effects Of Flurbiprofen Axetil And Tramadol On Improved Uppp

Objective:To observe the analgesic safety and efficacy of flurbiprofen axetil and tramadol on the improved uvulopalatopharyngoplasty (UPPP).Methods:60 ASA Ⅰ-Ⅱ patients received UPPP under general anesthesia, aged 18-60 years old and with weight between 60 and 85kg were enrolled in this study. They were randomly classified as 3 groups, including Group A (blank group), Group B (tramadol group) and Group C (flurbiprofen axetil group). Patients were injected 0.9% normal saline (5ml), tramadol (100mg) and flurbiprofen axetil (50mg), intravenously at 15min before the end of surgery. Observation & Records:General information of patients such as age, weight, duration of operation and extubation. Heart rate, blood pressure and oxygen saturation at 5min after entering into operation room (T1),15min after injection (T2), immediately after extubation (T3), post-operative 2h (T4), post-operative 4h (T5), post-operative 8h (T6) and post-operative 24h (T7); Visual Analog Scale for Pain (VAS Pain) and Body Condition Scoring (BCS) at 2h,4h,8h and 24h after operation were; number of analgesic administration within 24h, as well as adverse reactions such as dizziness, nausea, vomit, pruritus, respiratory depression, etc.Results:1. The differences between general information of patients in 3 groups (age, weight, duration of operation and extubation) were not statistically significant (p>0.05).2. Systolic pressure, diastolic pressure and heart rate of patients in 3 groups at T1, T2, T3, T6 and T7 presented no statistically significant difference (p>0.05). The systolic pressure, systolic pressure and heart rate of Group C decreased remarkably at T4 and T5 compared to Group A and B, and there were statistically significant differences (p<0.05); SPO2 at each time point of patients in 3 groups showed no statistically significant difference as p>0.05.3. VAS scores of Group B and Group C at post-operative 2h,4h and 8h were lower than Group A, and there was statistically significant difference (p<0.05). While, VAS score of Group C at post-operative 4h was lower than Group B, showing statistically significant difference as p<0.05. The difference for VAS scores of all the three groups at post-operative 24h was not statistically significant (p>0.05).4. BCS scores of Group B and Group C at post-operative 2h,4h and 8h were higher than Group A, which presented statistically significant difference (p<0.05). While, BCS score of Group C at post-operative 4h was higher than Group B, showing statistically significant difference as p<0.05. The difference for BCS scores of all the three groups at post-operative 24h was not statistically significant (p>0.05). With respect to incidence of nausea and vomit within 24h, Group B was higher than the other two groups, showing statistically significant difference as p<0.05; statistically significant difference for incidence of dizziness for the three groups was found, with p>0.05; no pruritus and respiratory depression occurred on the patients of 3 groups.5. For the number of analgesic administration within 24h, Group B and C was less than Group A, which presented statistically significant difference as p<0.05.Conclusion:1. Treating UPPP postoperative analgesia with flurbiprofen axetil and tramadol are safe and feasible.2. Flurbiprofen axetil showed less adverse reaction than tramadol in terms of UPPP postoperative analgesia. 3. from the point of the incidence of adverse reactions, and vomiting rate of tramadol group was obviously higher than that of flurbiprofen ester group.