The Efficacy Observation Of Pediatric Ma Gan Particles On Wind-heat Close Lung Type And Phlegm-heat Close Lung Type Bronchiolitis

BackgroundBronchiolitis mostly viral infections, bronchiolitis (infection) there is no effective antiviral Western medicine treatment alone, the clinical treatment given symptomatic and supportive therapy, the efficacy is not ideal. Some years, many pediatricians choose oral proprietary adjuvant therapy for children with bronchiolitis the "polio Gan particles", to achieve better efficacy in clinical practice, and to avoid the lack of Pieces of Chinese medicine formulations of oral way and thus continue to promote clinical. Polio Gan particles as the preparation of patent Chinese medicines, treatment principles should also follow the theory of traditional Chinese medicine, but the drug instructions but the lack of a corresponding type of TCM Treatment, and treatment literature reported no dialectical therapy. The the TCM syndrome certificate type bronchiolitis there are a variety of and proprietary Chinese medicine prescription consists of fixed subtraction with the card can not be clinically screened for polio Gan type of particle therapy TCM is the urgent problem.purposesThis issue through objective evaluation of pediatric Ma Gan particles heat syndromes bronchiolitis TCM syndrome belongs to the (Syndrome of wind-heat-lung and Syndrome of phlegm-heat close Lung) difference in efficacy between the various syndromes discussed more suitable for children Ma Gantype of particle therapy TCM. MethodsThis study stratified randomized controlled trial Methods:December2012to March2013in the South China Sea, Guangzhou University of TCM affiliated Children’s Hospital of Obstetrics and Gynecology Internal Medicine Residency children and meet the requirements of children with a total of120cases, including wind and heat Closed lungs and phlegm off the Lung60cases each; each syndrome group was randomly divided into control group,30patients in each treatment group. The treatment group and the control group were given "conventional therapy":oxygen inhalation (budesonide, ipratropium, terbutaline), to correct acid-base balance, sedation, improve pulmonary microcirculation and enhance nutrition support treatment, if necessary, to give antibiotics to treat secondary bacterial infections (routine use of antibiotics does not affect the course of the disease,"Pediatrics"); treatment group in the "conventional treatment" based on the use of children Ma Gan particles (Jianmin Suizhou China Pharmaceutical Group Limited, Zhunzi Z42020897) combination therapy. Ma Gan particles Pediatric Dosage:oral; Children under one year old, one0.8g, one to52, once1.6g;3times a day; seven days for a course of treatment. Before the start of treatment baseline data analysis, including general clinical data (gender, age, weight), pre-hospital course and admission syndrome integral aspect. After the start of treatment, the main symptoms of the disease were observed and recorded, positive signs disappearing time, clinical recovery time, as well as a course of treatment after symptom scores, efficacy results, etc., to establish a database for statistical analysis using SPSS13.0.ResultsThis study showed that pre-treatment, wind and heat off the lung-and phlegm off Pulmonary two groups of children, which belongs to the syndrome treatment group and the control group in the general clinical data (gender, age, weight), duration of admission as well as all aspects of admission syndrome score compared by statistical analysis, p>0.05, the above tips syndrome belongs to the treatment group and the control group between baseline data showed no significant difference between the two groups were comparable.After a course of treatment (7days), respectively, based on the wind and the heat off the lung phlegm off the lung-type groups of children belongs treatment group and the control group syndrome score, the main symptoms, positive signs disappearing time, clinical recovery time and efficacy results were compared between groups:①wind heat off lungs:The above data by the statistical analysis, the p>0.05, the two groups of children in the above no significant difference between the treatment group and treatment programs no better than the control group, namely wind and heat treatment of bronchiolitis when closed lungs "Ma Gan particles combined with routine pediatric treatment" effect is not better than the "simple routine treatment";②phlegm off lungs:The above data were statistical analysis, the p<0.05, the two groups of children in the comparison of the above there are significant differences in the treatment group than the control group treatment programs that treat phlegm off pulmonary capillary bronchitis "Pediatric Ma Gan particles combined with routine therapy "more effective than" conventional therapy alone.ConclusionsThe polio Gan particles combined with conventional treatment in the phlegm-heat the closed lung bronchiolitis in efficacy superior to conventional therapy alone; no significant difference in the wind and heat off the lung bronchiolitis in the efficacy of conventional treatment alone. The pediatric Ma Gan particles more suitable for the treatment of bronchiolitis TCM type type phlegm off the lung. Pediatric Ma Gan particle treatment of bronchiolitis, should do distinguish disease sub-type, diagnosis and treatment, the only way to improve efficacy.