| Backgroud Polio(poliomyelitis), also known as polio, is an acute infectious disease caused by the polio virus. Mostly no paralysis or occult infection cases when popular, a higher incidence of children than adults, major health hazard for children under 5 years old, it can cause irreversible paralysis of limbs or even death in few people.Objective By detecting healthy people’s serum antibody titers and vaccination surveys on 1-6 years children in Ningxia, to evaluate immunity levels and effects of vaccination in polio virusⅠ, Ⅱ, Ⅲtype in Ningxia healthy people, to provide reliable data to support Ningxia vaccination immune effects and to provide guidance for routine immunization and supplementary immunization activities.Methods Using stratified cluster sampling method, Each city randomly selected two counties in 22 counties of five cities in Ningxia, The PPS method was used to select four villages(neighborhood) in each extracted county and 1200 residents were surveyed. The study included questionnaire survey and the detection of three type polio serum antibody titer. The survey included: basic information about the respondent, the history of disease and vaccination. Antibody titer were detected by neutralizing antibodies test method.Results TypeⅠantibody positive rate was 97.25%(1165/1198) in 1198 healthy residents while neutralizing antibody GMT was 1: 142.26. Type Ⅱantibody positive rate was 97.58%(1169/1198), while neutralizing antibody GMT was 1: 96.74. Type antibody positive rate was Ⅲ94.24%(1129/1198), while neutralizing antibody GMT was 1: 53.18. The difference of three typed antibody positive rate showed statistically significant(P <0.01). Difference on and Ⅰ Ⅲ, Ⅱ and Ⅲantibody positive rate showed statistically significant, respectively(P <0.01), while Ⅰ and Ⅲantibodies rate was no significant difference(P = 0.607). Polio virusⅠ, Ⅱ, Ⅲneutralizing antibody GMT difference showed statistically significant(P <0.01). Neutralizing antibody GMT difference between and Ⅰ Ⅱ, and Ⅱ Ⅲ, Ⅰand wⅢ as statistically significant, respectively(P <0.01). Difference of Ⅰ, Ⅱ, Ⅲtype antibody positive rate among age groups showed no significant difference(P> 0.05). The difference among different age groups inⅠ, Ⅱ, Ⅲ type of neutralizing antibody GMT was statistically significant(P<0.05) and the neutralizing antibody GMT decreased with age increasing. Antibody positive rate and neutralizing antibody GMT in the three type polio between different gender showed no statistically significant difference(P>0.05). The difference of type Ⅰpolio neutralizing antibody GMT between Hui and Han ethnic group had statistical significance(P<0.05) and Hui’ neutralizing antibody GMT was higher than the Han’. The difference of polio virusⅠ, Ⅱ, antibody positive rⅢ ate and Ⅱpolio neutralizing antibody GMT between different living residents was no statistical significance, while the difference of polio Ⅰ, Ⅱneutralizing antibody GMT between different living residents showed statistical significance(P<0.05). Township residents’ neutralizing antibody GMT was higher than that in urban residents. the differences ofⅠ, Ⅱ, Ⅲtype antibody positive rate and Ⅱ, Ⅲpolio neutralizing antibody GMT between different regions were no statistical significance, while the difference of typeⅠpolio neutralizing antibody GMT between different regions showed statistical significance(P = 0.044),Display Ling Wu residents neutralizing antibody GMT is higher than other regions.The difference of composition between Polio virus Ⅰ, Ⅱ, Ⅲ neutralizing antibody GMT was statistically significant(P<0.01), while the difference of distribution betweenⅠand Ⅱ, Ⅱand Ⅲ, Ⅰand Ⅲpolio neutralizing antibody GMT showed statistical significance(P<0.01). The Comparison of three Type polio neutralizing antibody GMT between different genders displayed that type Ⅰ, Ⅱwas no significant difference(P>0.05), while the difference of Ⅲneutralizing antibody GMT composition between two genders in was statistically significant(P<0.05). Comparing the difference of the composition in Polio virusⅠ, Ⅱ, Ⅲ neutralizing antibody GMT between two ethnic group by X2 test, the results showed that there was no significant difference(P> 0.05). The overall trend was increasing at first and then decreasing.The difference of the composition in Polio virusⅠ, Ⅱ, Ⅲ neutralizing antibody GMT between different living residents showed statistically significant(P> 0.05).Inoculation rates of the 360 healthy children at the first dose, the second dose, third dose, who were 1-6 years old, was 99.44% and the reinforce vaccination rate was 92.16%. No significant difference of polio vaccination rate was found in different age groups, gender, ethnicity, region, type of residence(P> 0.05). The counties’ three doses of vaccination coverage were 100% except in Xiji County and Haiyuan County. At the qualification rate of three times in this survey, the qualified rate of first dose was 82.07% while deferred vaccination rate, ahead of inoculation rate, unvaccinated rate were 15.69%, 1.68%, 0.56%, respectively. The qualified rate, deferred vaccination rate, ahead of inoculation rate, unvaccinated rate of the second dose vaccination were 81.79%, 17.65%, 0.00 and 0.56%, respectively. The qualified rate, deferred vaccination rate, ahead of inoculation rate, unvaccinated rate of the third dose vaccination were 80.95%, 18.21%, 0.28% and 0.56%, respectively.Conclusion Polio antibody positive rate and GMT polio neutralizing antibodies generally remained at a high level in three healthy population of Ningxia. Children vaccination rate at 1-6 years old remained at above 99% and formed a good immune barrier. However, the qualified vaccination rate is still in a very low level in Ningxia. |
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