Dynamical Changes Of Anterior Pituitary Hormones In Patients With Traumatic Brain Injury And Its Clinical Significance

Objective：To explore the correlation of changes in the anterior pituitary hormoneswith the severity and prognosis in patients with traumatic brain injury.Methods: Fifty patients with traumatic brain injury in Dalian Central Hospitalwere randomly selected from May2010to December2011for the observationgroup.The dynamic levels of changes in prolactin(PRL), growth(GH),throid stimulatinghormone(TSH), luteinizing hormone(LH), and follicle stimulating hormone(FSH) werestudied within24hours, third day, fifth day, seventh day, fourteenth day after trauma.The relationship between the changes in the anterior pituitary hormones and the severityof the traumatic brain injury or the prognosis was analyzed.Results:The PRL and GH value of the observation group was significantlyincreased.The PRL and GH value of the midrange and severe traumatic brain injurygroup, the light and deep coma group, herniation group and poor prognosis group weresignificantly higher than the upper limit of normal reference value（P＜0.05）.The moresevere the traumatic brain injury was, the higher the pituitary PRL and GH was,theworse the prognosis was;In dynamic observation,the level of PRL and GH dropped fast,the change of amplitude was great, the speed of recovery was slower, the worse theprognosis was. Compared with the normal reference values, there were not significantchanges in the levels of TSH、FSH and LH.Conclusion: The immediate changes and dynamic changes in PRL and GH aftertraumatic brain injury (TBI)can be used as a guideline for judging the severity of traumaand estimating the prognosis of patients.