Study On The Correlation Between Serum Pituitary Hormone Levels And Depression In Patients With Mild Traumatic Brain Injury

ObjectivesTo investigate the relationship between serum pituitary hormone levels and depression of mild traumatic brain injury patients.MethodsThe clinical data of 67 patients with mTBI from March 2019 to December 2019 in Shanghai Jiaotong University Affiliated Sixth People’s Hospital South Campus were collected.The serum hormone levels of patients was detected by ELISA assay and the patients were followed up for 6 months to one years.The self-rating depression scale(SDS)was used to evaluate the depression of patients.Patients with SDS score≥53 were included in the depression group,and the remaining patients were non-depressed.The serum levels of various hormones in the two groups were compared.The binary logistic regression analysis method was used to analyze the risk factors of depression in mTBI patients.ResultsThe follow-up SDS score of the depression group within one year after discharge was(57.21±2.275)points,which was significantly higher than the non-depression group[(47.33±4.204)points,t=-6.700,P<0.05];The level of serum adrenocorticotropic hormone(ACTH)in depression group was higher than that in non-depression group[(22.85±9.25)pg/ml vs(14.48±9.27)pg/ml,t=-3.31,P<0.05];The level of serum corticotropin releasing hormone(CRH)in depression group was higher than that in non-depression group[(20.10±9.83)pg/ml vs(14.35±10.43)pg/ml,t=-2.067,P<0.05].The level of serum BDNF in the depression group was lower than that in the non-depression group[(4.35±2.82)ng/ml vs(12.72±10.91)ng/ml,t=-3286,P<0.05];The ACTH level of the depression group was positively correlated with the SDS score(r=0.261,P<0.05);the results of binary logistic regression analysis showed that mTBI patients with high serum ACTH levels were prone to depression.(OR=0.910,95%CI:0.833～0.994,P<0.05).The level of BDNF and SDS score in the depression group was negatively correlated(r=-0.321,P<0.05);the results of binary logistic regression analysis showed that mTBI patients with low serum BDNF levels were prone to depression(OR=0.707,95%CI:0.572-0.875,P<0.05).There was no significant difference in depression group and non-depressed patients with serum TSH,TRH,EPI,5-HT and DA levels,etc.Conclusion(1)Serum ACTH and CRH levels of depressed patients after mTBI were significantly higher than those of non-depressed patients;(2)The serum BDNF level of depressed patients after mTBI was significantly lower than that of non-depressed patients;(3)This study suggests that abnormal levels of serum ACTH and BDNF in patients with TBI in the early stage are risk factors for later depression.It can simply predict whether the patient will experience depression,but the authority and reliability still require follow-up clinical research.Figure[4]table[7]reference[68]...