Liver Heat Spleen Method Of Clinical Research For The Treatment Of Generalized Anxiety

ObjectiveThe research is supported by the city of Beijing the first fund major joint project 《generalized anxiety disorder symptoms of TCM》, this project aims to study the GAD and get clinical evaluation of TCM in the treatment of GAD. We can recognize the clear clinical effect, safety and the range of treatment.We can confirm the results and provide a basis for formulating the standard of GAD of TCM treatment plan.Medthod:The research collection period was from October2009to December2011. The data were collected from The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine in63patients,25were male,38female; aged between from17to78years old; occupation of the office staff of11people, retiree21people, freedom of occupation in7people,8people of worker, farmer of9people and6students. On the basis of professor Tang Qisheng of basic research and clinical experience, the fire of liver qi stagnation is the most common GAD syndromes. By using a randomized, controlled, double-blind method of observation,through HAMA and the scale of TCM symptoms and to compare the curative effect of Chinese medicine dan zhi xiao yao san with the Deaxit on GAD with hotness and stagnancy of liver-qi.63GAD patients with the fire of liver qi stagnation were observed for6weeks in a randomized controlled clinical trail with dan zhi xiao yao san and HAMA and the scale of TCM symptoms were applied to measure the treatment effect.Results:We found that the score of HAMA of the total effective rate of both2groups after therapy decreased significantly (p<0.05) after1、2、4、6weeks. And the score of TCM symptoms scale of experimental group after therapy also decreased significantly (p<0.05)except the first week. There was no serious side effects in control group occurred. And there were fewer cases with side effects in control group occurred, there were dry mouth,sweating and fremitus of body.Conclusion:1. Method of soothing the liver and alleviating depression, strengthening the spleen and clearing away heat of generalized anxiety disorder has a better therapeutic effect, and no obvious toxic and side effect, prompting the Chinese medicine in the treatment of anxiety disorders has certain advantages.2. Dan zhi xiao yao san on spleen deficiency syndrome with features of significant symptoms, such as loss of appetite, abdominal distension, curative effect is obviously superior to lorazepam, to improve sleep, mouth xerostomia have obvious curative effect.