Correlation Study Of Cerebral Blood Flow Autoregutation And Anxiety Disorder

Background: Recent studies have found that cerebral blood flow autoregulationdysfunctionis correlated with many diseases development and advances, especiallycerebrovascular diseases. Anxiety disorder is a blanket term covering several different formsof a type of common psychiatric disorder characterized by Palpitations, shortness of breath,sweating, dizziness and headache, which is frequently misdiagnosed as psychological causesand does not arouse more attention in clinic.In our previous study, we analyzed the dynamicchanges of CBFV in response to an orthostatic challenge using transcranial Doppler (TCD),and found that cerebrovascular modulation is compromised in anxiety; anxious subjects havesome insufficiency in maintaining cerebral perfusion after postural change. In the presentstudy, we assessed the changes of cerebrovascular modulation before and after treatment inpatients with anxiety.Objective: To study the correlation Study of autoregulation cerebral bloodflow andanxiety disorder.Methods: Subjects with Hamilton anxiety scale scores≥14were enrolled and the dynamicchanges of CBFV in response to an orthostatic challenge were investigated using transcranialDoppler. Then we offered treatment and followed up for6months,and recorded the dynamicchanges of CBFV values again。Results:1、Compared to healthy group, the mean CBFV was remarkably reduce inanxiety disorder groups from supine to upright (5.88±5.549cm/s vs2.75±2.615cm/s, P<0.05);2、The recovery group demonstrated significant improvement in changes in the mean CBFVvalues from the supine to the upright position after treatment than before treatment(7.23±5.41cm/s vs2.41±3.04cm/s, F=10.26, P=0.03).And after treatment, the significantdifference was disappeared (2.41±3.04cm/s vs2.75±2.62cm/s, Z=-0.136，P=0.896); Theunrecovery group demonstrated no difference in the mean CBFV values from the supine tothe upright position after treatment(65.3±12.04cm/svs65.4±9.87cm/s, F=0.001, P=0.98), Compared to healthy group，there still have remarkablely difference(6.78±3.97cm/s vs2.75±2.62cm/s,P<0.05);3、Contrasted with control group, the heart rate difference wasincreased(-12.68±10.015beats/min vs-8.97±6.696beats/min, P<0.05), And after treatment,the significant difference was disappeared (-8.36±7.23beats/min vs-8.97±6.696beats/min，P>0.05)4、the mean CBFV and was no difference amongmild、moderate、severe anxietydisorder (63.10±14.41cm/svs65.57±10.93cm/svs64.63±11.76cm/s， F=0.31， P=0.72)(5.12±6.28cm/s vs6.83±4.96cm/s vs6.76±5.06cm/s, F=1.39, P=0.25).Conclusion: The mean CBFV was remarkably reduce in anxiety disorder patients fromsupine to upright. This shows that impaired cerebral autoregulation is existed in anxietydisorder sufferers.However, dynamic monitoring of the CBFV curve from the anxiety patientsshowed that the impaired cerebral autoregulation can restore to normal after anxietydisappeared, early intervention therapies may reduce the incidence of cerebrovascular diseasein anxiety patients.