Study Of The Correlation Between Pentraxin3and Acute Coronary Syndrome

BackgroundAcute coronary syndrome(ACS) is a kind of atherosclerotic disease threatening people’s life.Usually,the atherosclerotic plaque surface erode and rupture,leading to acute thrombosis and causing the blood of coronary artery decreased seriously and suddenly.Presently,the studies had found that the inflammation and immune play a part in multiple of ACS.Hs-CRP is a inflammatory maker known extensively playing important clinical significance in diagnosis and prognosis of coronary heart disease(CHD).CTnI,as a maker of acute myocardium lesion,has been used to diagnose ACS in clinic extensively.PTX3which was found recently increased significantly in patients with ACS.However,comparing with other markers,there is few of researches about its sensitivity and specificity of diagnosing ACS and the correlation with the severity of coronary artery lesion.ObjectiveTo evaluate PTX3’s sensitivity and specificity of diagnosing ACS,the correlation between PTX3levels and the coronary artery lesion.Methods1. In the study,we examined75patients from October2010to September2011at the department of Cardiology in An yang People’s Hospital,who underwent coronary angiography(CAG).According to the clinical manifestation and the result of CAG,all the subjects were divided into two groups:non-ACS group with32cases consists of12cases without significant narrowing in CAG and20patients with SA;ACS group with43patients consists of18patients with UA and25patients with AMI. 2. All the patients were collected serum samples immediately to measure the levels of PTX3、hs-CRP and cTnI after being hospitalized.3. All the cases underwent CAG recording the situation of coronary artery lesion and calculating the criteria points of all subjects according to the Gensini standard.Result1. The comparison of baseline clinical characteristic such as age、sex、hypertension、 diabetes、smoking、FPG、TG、TC、LDL-c and HDL-c among non-ACS and ACS groups or among control、SA、UA and AMI cases have no obvious statistical difference(P>0.05).2. The level of PTX3and conventional factors:the levels of PTX3wasn’t different between male and female(P=0.547);the levels of PTX3were not significant difference between with and no conventional risk factors,such as diabetes(P=0.810) hypertension(P=0.692) and smoking(P=0.111).In addition,neither TG(Correlation coefficient r=-0.138, P=0.239), TC(Correlation coefficient r=-0.116,P=0.324)、 LDL-c(r=-0.034,P=0.775)、HDL-c(Correlation coefficient r=-0.103,P=0.2378),nor age(Correlation coefficient r=-0.074,P=0.525),circulating PTX3levels were not significantly correlated with them.3. The analysis of PTX3between non-ACS group and ACS group:circulating PTX3levels were significantly higher in ACS than non-ACS(P<0.001).4. Correlation of PTX3with hs-CRP and cTnI:serum PTX3levels showed correlation with cTnI levels(Correlation coefficient r=0.377,,P=0.001), however,their correlation with hs-CRP levels was not statistically significant(Correlation coefficient r=0.215,P=0.0.064).5. Diagnostic values of PTX3for ACS:to compare the diagnostic sensitivity and specificity of hs-CRP and cTnI,receiver operating characteristic (ROC) curves for the detection of ACS were compared.Sensitivity and specificity of PTX3for the diagnosis of ACS appear to be higher than hs-CRP and cTnI.Area under the curve(AUC) values for PTX3、hs-CRP and cTnI were0.905,0.795and0.748.6. Correlation of PTX3with Gensini points:there wasn’t correlation between the PTX3levels and the Gensini points of ACS subjects(Correlation coefficient r=0.279P=0.070).Conclusion1. PTX3is correlation with ACS.It can be considered as one of the indexes to judge the degree of CHD and be able to judge the seriousness of CHD.2. In the early stage of ACS,PTX3showed higher sensitivity and specificity than hs-CRP and cTnI,with higher accuracy for detecting early ACS.3. There wasn’t correlation between PTX3and the severity of coronary artery lesion for ACS,so we cann’t evaluate the severity of coronary artery narrowing making use of PTX3.