Serum Levels Of Angiopoietin-1, Angiopoietin-2and Their Receptor Tie2in Patients With Nasopharyngeal Carcinoma

Objective:To investigate the serum levels of angiopoietin-1angiopoietin-2and their receptor Tie-2in patient with nasopharyngeal carcinoma(NPC).Methods:The study consist of68patiants (32untreated cases,20cases with complete remission and16recurrent cases) with NPC and the control group of20healthy controls.The serum concentrations of Ang-1、Ang-2and Tie-2were measured by enzyme-linked immunosorbent assay (ELISA).Results:Compared to normal control group, the levels of angiopoietin-1、 angiopoietin-2and receptor Tie-2in NPC patients with untreated and relapsed groups was significantly increased (P<0.01).Only the concentrations of angiopoietin-2and receptor Tie-2was closely correlated with T and clinical stages(P<0.05). The serum concentration of Ang-2and receptor Tie-2tended to increase with the development of tumor. The concentration of Ang-2was closely correlated with N stages(P<0.05).There was significantly difference amonge Ang-2and receptor Tie-2concentration between tumor metastasis and nonmetastasis group. Moreover,it was observed that the Ang-1/Ang-2ratio was statistically different in T stages、N stages and clinical stages(P<0.05). Conclusions:Ang-1、Ang-2and receptor Tie-2may play an important role in the progress of NPC,and may have a close relationship with the invasion and metastasis of the tumor..