| Objective: To understand clinical characteristics and epidemiology ofvitiligo, understanding related genetic factors and environmental factors in theoccurrence of disease.Methods: The clinical cases were from patients attending dermatology inour hospital in October2010to2011in December, the diagnosis was made bytwo experienced physicians, and the exclusion of other causeshypopigmentation disease of skin and mucous membrane, such as pityriasissimplex, tinea versicolor, nevus anemicus, piebaldism, post-inflammatoryhypopigmentation and other diseases, by experienced registrar to registergeneral information and family history about patients. Ultimately get a total of850vitiligo epidemiology registration table and800control tables. Accordingto the case group and control group, using SPSS17.0software for statistical,analysis and obtained the corresponding results.Results: Of the850vitiligo patients,410(48.24%) were men and440(51.76%) were women, male to female ratio of1:1.07; The average maleage of onset (19.19±12.06years) earlier than the female (21.04±13.49years),there was found to be statistically significant differences (F=1.25, P=.0243).The patient group’s mean onset age was20.15±12.85years (range0-85years),37.88%patients had onset before the14years of age,81.65%patientshad onset before30years of age, so The incidence of vitiligo mainly involvingchildren and young people. Hundred and twenty one(14.24%)patients had anassociated premature greying. Hundred and fifty-three(18.00%) patients had anassociated itch before the onset. onset age of itching patients (23.75±12.94years) was greater than non-itching(19.35±12.71years),there were found tobe statistically significant differences(t=3.857, p <0.05). The summer was topped the list(42.35%), followed by spring (22.00%) inthe primary onset season of vitiligo patients.The most common site of onsetwas the head and face (36.61%), followed by the trunk (24.23%),and the upperlimb was part of the least(3.64%).In comparison to onset site of vitiligo patientswith vitiligo this sex difference was found not significant （χ2=11.12，P=0.08）.Vitiligo focal (55.56%) was the most common typein starter type,followed by acrofacial (19.85%) and vulgaris(16.21%). however, vulgaris（44.94%） was the most common type in treatment type in our hospital,folloewd by localized (27.76%) and segmenta（l15.06%）. Sex and onset typedistribution of the two groups were compared and the difference wasstatistically significant（χ2=16.66，p=0.002）, men onset type mainly wasacrofacial and women was segmental. There were statistically significantbetween different type and onset age (F=2.41，P=0.0478), the mean age at onsetof segmental vitiligo patients was earlier than other ype（17.92±11.74years）.Mixed vitiligo was in the classification of vitiligo in addition to segmental andnon segmental vitilgio, the proportion of small (1.06%).686(80.71%) wereprogress and164(19.29%) were stability.With the164positive family history,61of the first-degree relatives,53ofthe second-degree relatives, and30of the third-degree relatives of probandswere also affected with vitiligo (37.20%,33.54%,and18.29%,respectively). Themean age at onset between positive (19.82±11.56years old) and negativefamily history (20.22±13.15years) was no significantly different (t=0.356, p=0.722), and different type was also no significantly different (χ2=5.1625, P=0.271).Spirit factor was the dominant factors in the pathogenesis of vitiligo,followed by trauma and skin disease; mixed factors was mainly exacerbationfactors, followed by mental factors and trauma. Second-hand smoking was riskfactor for vitiligo（χ2=74.42，p＜0.0001）. Patients group of tea is about twice that of the control group, there were be found a significant difference (χ2=8.84,P=0.0029).Conclusion: Vitiligo was mainly involving children and young people, theonset age of men was earlier than women. vitiligo was most common occurs inthe spring and summer, and onset part was the head and face, primary typemainly was focal, treatment type was vulgaris. The age at onset of segmentalvitiligo was earlier than other type. Spirit factor was the dominant factors in thepathogenesis of vitiligo,and mixed factors was mainly exacerbation factors.Second-hand smoking is risk for vitiligo. Patients group of tea is about twicethat of the control group,. |
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