The Daqinglong Tang Granules Of Pharmaceutical Research

The daqinglong Tang (DQLT) decoction is the main prescriptions found in the "treatise on febrile disease". By ephedra, Cassiabarktree Twig, Fresh Ginger, Ansu Apricot Seed, Radix Glycyrrhizae preparata, Common Jujube, Gypsum,the daqinglong Tang(DQLT) granules composed of traditional Chinese medicine. The whole prescription has the cold outside scattered within the actual weight certificate; attending exogenous cold table real re-license, to rid the swelter patients make a relieving rheumatism and cold. The chief physician of Zhou Aijun in charge of this subject during the outbreak of the Influenza A (H1N1)(A stream) to use the classic recipe of clinical treatment hundreds of influenza patients, have a significant effect.To further enhance the efficacy of the DQLT classic recipe and to overcome the traditional decoction taking overdose bitter taste to carry the drawbacks of inconvenience, the subject of this thesis, to the development of the classic recipe into granules.To develop the preparation of quality standards and drug stability study as a solid foundation for the hospital preparation for its development.As the classic recipe is ensemble.By means of orthogonal design was investigated to made the other in Chinese herbal volatile oil and decoction extract and purification of the production process,have achieved a reliable technical parameters and got the transition to industrialization; the use of modern preparation techniques and accessories to select in the preparation process on the DQLT intermediates, dextrin dosage, granulation drying, whole granules critical relative humidity system study to determine the reasonable preparation process.Use of modern analytical methods,on the traits of the DQLT of particles,the TLC of the determination of a variety of active ingredients, preparation of tablets, the melting of the granules, the load difference as well as heavy metals, arsenic salt, moisture inspection etc.system to develop quality standards of the traditional Chinese medicine can effectively control the intrinsic quality of the DQLT particles.In accordance with the guiding principles of Chinese medicine natu-ral drug stability, the use of accelerated testing and at room temperature for two research methods, in accordance with the DQLT particles above the quality standards developed for the detection basis of the the DQLT of particles, The stability of the drug were studied. The results show that,all the indexes did not change significantly,indicating that the stable quality of the DQLT particles in the warranty period, which provides the basis for its clinical use.Reference issued by the guiding principles of Chinese medicine natu-ral drug stability, to acute toxicity test on the DQLT particles.Research results by spss18.0software processing,the amount of granules have mice fed granules quite adult clinical daily dose220.98-fold, indicating that the preparation is less toxic, safe range.