Chuanxiong Formula Particles Pharmaceutical Research

The study on standard of Chuanxiong Gispensing Granules belongs to one of the important stated items. With the guidance of Traditional Chinese Medicine theories and Pharmacy, according to the standard related law, Chuanxiong Gispensing Granules has been studied on pharmacy by adopting the modern pharmaceutical techniques.The main work of this paper is the research of Chuanxiong Gispensing Granules which includes the preparation technology, quality standards, stability, isoeffect of pharmacodynamic action, and acute toxicity research.Chuanxiong Gispensing Granules is produced from the single traditional Chinese medicine. According to the medicine's physical features of the effective parts, pharmacology research, and clinic requirements, its technique parameters are confirmed. Through semi-works production testing, this technology is approved to be effective.The quality standards research consists of the cut crude drug and adjuvant quality standards research and praeparatum quality standards research. One main work of the cut crude drug quality standards research is to study the character, identification, checking, and extract of the cut crude drug. Another work is to research the assaying which is not included in the pharmacopoeia. The main work of praeparatum quality standards is to research the character, identification, checking, extract, and assaying of the all three groups of samples; to adopt the TLC using the Chuanxiong comparing medical material; to regulate the ethanol extract and the content of ferulaic acid. Using this method, the transferring rate is larger than 60 percents, while the loss in the producing procedure is much more less.After the testing of the all three groups of samples, the Chuanxiong Gispensing Granules is approved to be well stable.Through comparing the pharmacodynamic action of Chuanxiong Gispensing Granules and cut crude drug using analgesia, algomenorrhea, and blood stasis animal models respectively, the experiments result indicate that these two medicine has no nominated differences. The acute toxicity indicates that Chuanxiong Gispensing Granules is good at security comparing with the cut crude drug. There's no big difference between these two medicines although their maximum tolerated dose are both much larger than the clinical usual dose.The pioneering research of the Chuanxiong Gispensing Granules fingerprint in this paper may be references to some other relative researches.Consequently, the expected goal is achieved in the research. Its results may help solve some common technical problems in the Traditional Chinese Medicine Gispensing Granules researches.