Clinical Efficacy Study Of Periodontal Therapy On Improving Renal Dialysis Microinflammatory State In Patients

Objectives: To investigate the effect of initial periodontal therapy on chronic kidneydisease (CKD) patients with periodontitis periodontal clinical index, the serumnephropathy clinical index, the concentration of IL-6and TNF-αin gingival crevicularfluid. Methods: Choose28patients undergoing hemodialysis associated with periodontaldisease with CKD, implementation of oral health instruction, ultrasonic scaling and rootplaning, periodontal treatment, conducted at baseline and after6weeks, conductedperiodontal examination, serum was collected for nephropathy associated with clinicalindicators of detection, and collected gingival crevicular fluid and determination IL-6andTNF–α in gingival crevicular fluid by enzyme-linked immune adsorption (ELISA)method. Results: Before and after periodontal treatment, periodontal clinical index of PLI(plaque index), PD (probing depth), BI (bleeding index), AL (attactment loss), thedifference was statistically significant (P <0.01), before and after periodontal treatment,the concentration of TNF-α and IL-6in gingival crevicular fluid, had no obviousdifference (P>0.05), there was no significant difference before and after treatment.Before and after treatment, nephropathy blood related biochemical index, creatinine、blood urea nitrogen、serum cystatin c, parathyroid hormone, had significant difference (P<0.05), the difference was statistically significant. The remaining three other indicators,uric acid, BUN/CR, acid phosphatase, before and after treatment there were nosignificant difference (P>0.05). Conclusions: Periodontal treatment can reduce theclinical periodontal indexes, at the same time, blood biochemical indexes for renal patientsindividual level also had a significant effect, do have control gingival inflammation, andpossibly in some extent can reduce renal dialysis patients with renal function damage andmicroinflammatory state.