A Meta-analysis Effect Of Non-surgical Periodontal Therapy On Inflammatory Factors In Patients With Chronic Kidney Disease And Periodontitis

Objective: Chronic kidney disease can show gradual decline of renal function,including the decrease of filtration rate of glomerulus and tubules.This is a complex and serious disease.Periodontitis is the result of the interaction of microorganism,host and environment.It is a common disease that endangers human oral health.However,there are some common risk factors between chronic kidney disease and periodontitis,which may affect the occurrence and development of the disease.The potential correlation between them may be found.A Meta-analysis was conducted to evaluate the clinical efficacy of inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy.These factors include C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-?(TNF-?).The aim of this study was to provide a new idea for the connection between different subjects by exploring whether non-surgical periodontal therapy could control the local and systemic inflammation.Methods: We searched the databases of CNKI,Wanfang,CBM,PubMed,EMbase and Cochrane Library from inception to December2019.Two reviewers independently collected all literature related to inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy.The literature was screened according to the inclusion and exclusion criteria.The quality of the studies was strictly evaluated,and the data were extracted.The literature of randomized controlled trials in accordance with the standards was Meta-analyzed with Revman5.3 software.Results: Six randomized controlled trials were included.Compared with the control groups,the results of Meta-analysis showed that non-surgical periodontal therapy significantly reduced the levels of CRP[MD=-0.58,95%CI(-1.13,-0.02),P=0.04]and IL-6 [MD=-2.76,95%CI(-5.15,-0.37),P=0.02] in these patients but not that of TNF-?[MD=-3.87,95% CI(-8.79,1.05),P=0.12].Conclusion: Simultaneous regular renal treatment and non-surgical periodontal therapy can help relieve the periodontal damage on patients with chronic kidney disease and periodontitis.Moreover,it can improve the status of some inflammatory factors.This finding is conducive to the control and treatment of chronic kidney disease and periodontitis and needs to be a focus of clinical research.