The Characteristics Of Executive Function And Event-related Potentials In Patients With Obsessive-compulsive Disorder

Objective:(1) This study was to explore whether patients with obsessive-compulsive disorder (OCD) have executive dysfunction in conflictive tack,and to explore whether this kind of executive dysfunction related to de subtype of obsessive-compulsive disorder.(2) the other purpose of this study is to investigate e is the executive function of obsessive-compulsive disorder will be affected bye the hard level of task.Methods:The obsessive-compulsive disorder patients and controls both completed the BD、Y-BOCS and STAI scales as well as the WCST. A new variant of high-conflict STROOP-color-word interference task with three different blocks was used in this study. In block one, incongruent trails take up30percent of total trails, the remaining trails were congruent trails. In block two, incongruent trails occupy70percent and congruent trails30percent. In block three, both incongruent and congruent trails take up50percent of the total trails.27patients who met CCMD-III criteria for obsessive-compulsive disorder and25healthy volunteers completed this task, and we analyzed the difference of the reaction time, error rate and interference effect between the OCD group and the control group.Results:(1) Both patients and controls observed interference effect, and the interference effect changed in different blocks.(2) There is no statistic difference between the score of the high-conflict STROOP corlor-word test bye OCD patients and controls.(3) Patients with obsessive-compulsive disorder have an increased activation in N2Conclusion:The current findings suggest that patients with obsessive-compulsive disorder have executive dysfunction in high-conflict STROOP-color-word interference task, and this kind of dysfunction has no relationship with the hard level of the interference task.