Dan To Cream In The Treatment Of Acute Swelling Closed Soft Tissue Injury Of Experiments

Purpose: Through the anti-inflammatory, detumescence, analgesic action and toxicity andskin to medicine safety of animal experiments, to study and confirmed to reduce swelling anointedapply Dan treatment of acute closed the damage of soft tissue clinical medical value, for morein-depth studies of the swelling of the cream to Dan mechanism to prepare for this party in clinicalsafety science and provide the basis for external use pharmacological experimental researchwiden their thoughts.Method: Use homemade used to attack successfully created the rat leg soft tissue damagemodel acute closed, choose LiaoYuan seven to for the control group scattered medicine, throughthe pharmacodynamics and toxicology of ten more classical experiment method, observe differentcomparison and analysis of the time damage index statistics results of symptoms, and separatelyfrom the experiment, learn it anti-inflammatory swelling experiment, skin permeability experiment,analgesic experiments and acute toxicity test and skin allergic experiment to explain and analyzesthe mechanism and drug safety.Result: Dan be swelling with an exact anointed role for activating blood circulation andeliminating stasis; Can inhibit fresh eggs made clear the swelling of the rat model foot; Can inhibitharpoons food made of plastic mold rats enough swelling; Can inhibit xylene-induced ear in micecaused by ear edema; Can inhibit histamine and serotonin of rats caused by skin permeability; Toimprove the rat mechanical stimuli pain threshold; Can inhibit acetic acid in mice caused the bodytorsion response; Topical rat skin and damaged skin complete did not cause acute toxicity reaction;Skin of guinea pigs do not have allergic reaction.Conclusion: Through the experiment proves Dan be anointed can quickly eliminate acuteswelling closed soft tissue injury caused by the bruises, swelling, pain, to speed up the local bloodcirculation and metabolism, improve tissue damage the environment around inside, reduce theZuZhiYe, and has anti-inflammatory, detumescence, the effect of analgesia, short-term use noobvious toxic and no skin allergic reaction.