| Objective:Through the pharmacodynamics experiment and the observation of chronic nasopharyngitis clinical curative effect, this paper aims to obtain an objective evaluation of the anti-inflammatory effect of Qiju (a kind of chrysanthemum) tea bag and the therapeutic effects for the chronic nasopharyngitis patients. Pharmacodynamics experiment mainly focuses on the research of the anti-inflammatory effects of the two experiments and attempts to get a comprehensive evaluation of the anti-inflammatory effects of the Qiju tea bag. One of the experiments is the mouse auricular swelling experiment and the other is mouse abdominal capillary permeability test.Meanwhile84cases of chronic nasopharyngitis cases are collected and randomized and a comparison between the before and after treatment groups is carried out to compare the symptoms, signs and body conditions thus to explore the treatment effects of Qiju tea bag on nasopharyngitis caused by the knotting of toxic heat in the body.Methods:1. According to "pharmacology experiment methodology", converse the dose according to the equivalent dose ratio of different experimental animals and people and prepare Qiju tea bag blisters fluid after conversion. The mice are randomly divided into five groups, including treatment group of high dose group, the dosage group, low dose group, standard control group and blank control group, all of which are treated with medicines, put to death and made as specimens and analysis of variance statistical data is collected according to the requirement.2. According to the traditional Chinese, western medicine diagnosis and differential diagnosis standard,84chronic nasopharyngitis outpatients are collected as subjects according to the requirements and are randomly divided into three groups:Qiju pharynx tea, Qiju tea bag group and control group. The subjects are required to take medicine, traced and interviewed and the medical record is collected. The relevant body check is done and the data is collected from the perspectives of total curative effect, efficient, significant efficiency, symptoms and signs of improvement status on statistical comparison.Results:1. Pharmacodynamics experimentmouse auricular swelling experiment:The rate statistics of swelling and swelling inhibition rate between the group significance is P<0.05, there was a significant difference between groups, within which swelling and swelling inhibition rate between the treatment group&control group and blank group achieve a significance P<0.05, with significance difference in statistics. The treatment group in the medium dose group of nose pharynx and QingDu particle group of anti-inflammatory effect achieve no significant difference now, which is better than that of the low dose group and high dose group; there is no significance difference between high dose and low dose groups.1.2The abdominal capillary permeability test results accord with the result of the mouse auricular tumefaction experiment results.2. Clinical observation2.1General information:all cases are collected from March2010to April2012at out-patient clinic of otorhinolaryngology service in the first affiliated hospital of Guangzhou university of Chinese traditional medicine.84patients are with complete and valid data and are divided into three groups, respectively Qiju pharynx tea, Qiju tea bag group and the control group, including11males,19females in the pharynx tea group;9males,15females in Qiju tea bag group;13males,17females in the control group. The average age of the Qiju pharynx tea is43.67±12.03, of the Qiju tea bag group is42.04±13.02and of the control group is38.00±12.07. In the pharynx tea group, there are3cases with alcohol and tobacco hobbies and27cases without alcohol and tobacco hobbies; In the Qiju tea bag group there are3cases with alcohol and tobacco hobbies and21cases without alcohol and tobacco hobbies; In the control group, there are3cases with alcohol and tobacco hobbies and27without alcohol and tobacco hobbies. Basically, the three groups have got an information balance, therefore they are comparable. Compare the total credit of symptoms and signs before the treatment, the pharynx tea group get the average21.07±7.23, the Qiju tea bag group get the average19.21±6.78and the control group get the average20.00±5.90and there are no statistics difference between groups, which is compared from the perspectives of cardinal symptom, secondary symptom and signs. There is no significant difference among the statistics before the treatment and basic information among the groups therefore they are comparable.2.2Compare the total curative effect, the pharynx tea group healed1case, accounting for3.3%;3cases were markedly improved, accounting for10.0%;26effective cases, accounting for86.7%, the total effective rate was100%; Qiju tea bag group healed2cases, accounting for8.3%,11cases were markedly improved, accounting for45.8%,9cases are effective, accounting for37.5%,2cases are invalid, accounting for8.3%; the total effective rate is91.7%; The control group healed0example,1cases was markedly improved, accounting for3.3%;24cases are effective, accounting for80%and the total effective rate was83.3%. Compared between groups, Qiju tea bag is better than that of the pharynx tea group and the control group is not as effective as the form two groups.2.3Efficient comparison:pharynx tea group and Qiju tea group was not statistically different and there is no significant difference between the Qiju tea bag group and control group; significant difference is achieved between the pharynx tea group and control group with P<0.05.2.4Significant efficiency comparisons:Qiju tea bag group was better than the control group and pharynx tea group and there is no statistical difference between the pharynx tea group and control group.2.5The comparison of cardinal symptom, secondary symptom and signs before and after treatment:the improvement of the cardinal symptom of the Qiju group is better than that of the pharynx tea group and control group and the pharynx group performs better than the control group; the improvement of the secondary symptom of the Qiju group and pharynx tea group are both better than that of the control group and there is no difference between the groups in improving the secondary symptoms; compared with the control group, the pharynx tea group and Qiqu tea bag group have the significant difference in improving the signs; there is no statistical difference between the Qiju tea bag group and pharynx tea group.Conclusion:The analysis of the significance of the ingredients of the Qiju tea bag: the prescription consists of6kinds of the Chinese herbal medicines, including Astragalus, wild chrysanthemum, mint and licorice, etc. All the medicine selected are of slight flavor and can absorbed by liver, lungs, spleen and meridians. Hence professor Qiu baoshan’s preciseness in prescription has been proved with the exquisite formula and overall consideration. The formula adjustment of the medicine taste attempts to make the tea faintly scented and pleasantly tasted.Through the mouse auricular tumefaction experiment research, the statistical difference is achieved among the treatment group, nose pharynx QingDu particle group and blank group on the degree of swelling, swelling inhibition rate and statistical comparison which represents the anti-inflammatory effect of Qiju tea bag and pharynx QingDu particles.In the mouse auricular swelling test, the medium dose group in the treatment group and the nose pharynx QingDu particle group have better effect than that of the low dose group and high dose group and there is no statistical difference between the medium dose group and the nose pharynx QingDu particle group, which shows that the Qiju tea bag has the similar anti-inflammatory with the nose pharynx QingDu particle in the Pharmacodynamics experiment and there is no significant difference between them. The medium dose group is better than that of the high and low dose groups and there is no significant difference between the low dose and high dose groups which shows the medium dose of the Qiju tea bag group has the best effect and the higher or lower dose of the Qiju tea bag would influence the Anti-inflammatory effect.The results of the abdominal capillary permeability test conform to the results of the mouse auricular swelling test, which further proofs the anti-inflammatory effect of the Qiju tea bag and demonstrates the best efficiency in the medium dose of the Qiju tea bag.In the temporarily observed cases, the Qiju tea bag has the best curative effect and the pharynx ranks the second and the control group ranks the third. When compared from the perspective of the efficiency, there is no statistical difference between the Qi ju tea bag and the pharynx tea group and no significant difference between the Qiju tea bag group and the pharynx group; nevertheless, significant difference exist between the pharynx tea group and control group. However, when compared from the significant efficiency, Qiju tea bag group has better effect than control group and there is no significant difference between the pharynx tea group and the control group which demonstrates that the curative effect of the Qiju tea bag and the pharynx tea are better than that of the nose and pharynx QingDu particles and the effect of the Qiju tea bag is more evident.Compare the improvement of cardinal symptom, secondary symptom and signs between before and after treatment, the cardinal symptom of the Qiju tea group have better improvement than the control group after taking the medicine, which shows that Qiju tea bag have better curative effect for the chronic nasopharyngitis; The improvement of the secondary symptom of the pharynx tea group and the Qiju tea group are better than that of the control group, which shows that both the Qiju tea bag group and the pharynx tea group are effective in curing the chronic nasopharyngitis and can be adopted to the symptom caused by the knotting of toxic heat in the body.The total curative effect in the Qiju tea bag group is better than that of the pharynx tea group, which shows that better effect can be achieved by changing the dosage. What’s more, the Qiju tea bag is convenient to take in and carried out and economical, therefore it is worthy of the efforts of promotion and application. |
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