Er-chen Decoction On Stable Angina Pectoris Of Coronary Heart Disease (Syndrome Of Phlegm Blocking Heart Vessel) In The Clinical And Experimental Study

ObjectiveEr-chen decoction in the treatment of coronary heart disease and stable angina pectoris(syndrome of phlegm blocking heart vessel), further through the animal experiments to explore the Er-chen decoction on spontaneously hypertensive rats with atherosclerosis cardiovascular intervention possible molecular biology, pathophysiology mechanism.MethodsFrom2011January to2012March period, from the first hospital of Guangzhou University of Chinese Medicine in cardiovascular department, emergency inside general ward and outpatient, with stable angina pectoris of coronary heart disease (syndrome of phlegm blocking heart vessel) patients a total of56cases. To be eligible in56cases were randomly divided into two groups, the treatment group of30cases,26cases of the control group. The experimental group received routine western medicine on the basis of, plus to er-chen decoction, the control group according to the condition of routine western medicine, the course of treatment was4weeks, with before and after treatment were symptom scale scores, the Seattle angina questionnaire integral change evaluation of its clinical efficacy. Animal experiments, SHR rats caused by atherosclerosis model (phlegm blocking heart vessel model), in the er-chen decoction intervened, and the establishment of the control group, further defined the er-chen decoction therapeutic effect for clinical treatment effect, thereby providing more powerful experimental evidence.Results1. Clinical analysis of test results show that, after4weeks of treatment, the experimental group and the control group in traditional Chinese medicine symptom scale and the Seattle angina questionnaire integral treatment had significant difference (P<0.05), the test group were significantly better than the control group (P<0.05); in improving symptoms of traditional Chinese medicine, experimental group in improving symptoms of traditional Chinese medicine curative effect is remarkable difference (P<0.01).2. Animal laboratory tips, Model group of myocardial fibers loose agglomeration separation, mitochondria, mitochondrial vacuolation, see figure land figure2. The statin group myocardial fibers in mild osteoporosis, mitochondria gathering, mitochondrial size, individual empty, see Figure3and figure4. Er-chen group myocardial fibers arranged relatively tidy, mitochondrial is better, the individual empty, as shown in Figure5to figure6. RT-PCR RhoA, Rho mRNA kinase expression level:three groups of rats myocardial RhoA mRNA expression level is shown in figure7. Comparison of three groups:Er-Chen was lowest, highest model group, Chen group and the statin group, P<0.01.Three groups of rats myocardial Rho kinase mRNA expression levels are shown in figure8. Comparison of three groups:Er-Chen was lowest, highest model group, Chen group and the statin group, P<0.01.Conclusion1. Er-chen decoction can on coronary heart disease patients with stable angina pectoris and alleviate the symptoms, improve the quality of life of patients, improve the prognosis, prove two delicacy soup in treating stable angina pectoris with distinct curative effect.2. Er-chen decoction by blocking Rho/Rho kinase signaling pathway, has on spontaneous hypertension with atherosclerosis rats cardiac remodeling have good effect.