Penehyclidine Hydrochloride Used As A Clinical Observation Of Patients With Gynecologic Laparoscopic Surgery

Objective: Hydrochloric acid penehyclidine used as a clinical observationof patients with gynecologic laparoscopic surgery Premedication.Method: Selected in October2011to January2012at the First Hospital ofJilin University gynecological elective laparoscopic surgery were60cases.ASA physical status I~II level, age19to53years(mean32.57±7.91years),preoperative cardiovascular system and central nervous system abnormalities,diabetes, and the use of atropine or Changtuoning to taboo Patients wereexcluded from the study. Were randomly divided into group A (control group),group B (atropine group), Group C (Changtuoning group),20patients in eachgroup. Preoperative routine fasting, water, three groups were30min in thepreoperative intramuscular injection of saline, atropine or Changtuoning0.5mg.Into the operating room the entire electrocardiogram (ECG), heart rate (HR),oxygen saturation (SpO2), noninvasive arterial blood pressure (NIBP)monitoring, open venous access, three groups of patients are midazolam0.04mg/kgetomidate0.2mg/kg of cis atracurium0.1-0.15mg/kg,, fentanyl5ug/kg, induction of anesthesia until the patient awareness after thedisappearance of the breathing mask pressurized oxygen for3min in thelaryngoscope orotracheal intubation under direct vision. Intravenoustarget-controlled infusion of propofol and remifentanil anesthesia wasmaintained. Three groups of patients in age, weight, surgery time, anesthesiatime was no significant difference (P>0.05).Were recorded before injection point in time T0to T1, before induction ofanesthesia, after intubation of T2,10min after pneumoperitoneum T3,extubation5min after T4inPatients venous blood3ml of T1, T2, T3, T4, four time points, the determination of plasma cortisol concentration, blood glucoselevels.Statistical analysis using the SPSS19.0software measurement dataexpressed as mean±standard deviation (±s), the group using paired t testbetween the two groups were compared using group t-test analysis, there wassignificant difference (P <0.05)..Result:1.B and C group there were significant differences in heart rate andsystolic blood pressure compared with group A control group (P <0.05), whilethe3groups compared with baseline values found in group A and group B arethere are significant differences (P <0.05), while the underlying value in the thethe application Changtuoning group before treatment compared with nosignificant difference (P>0.05).2.C in patients with T2(after intubation), T3(10min afterpneumoperitoneum), T4(5min) after extubation in cortisol compared to groupA significant difference (P <0.01).3. we can see from Table4.7, Group C patients with glucose in T2(afterintubation), T3(10min after pneumoperitoneum), T4(5min after extubation)compared with group A significant difference (P <0.05).Conclusion:1.Changtuoning as Premedication can better maintain the operation cyclestability.2.Changtuoning can significantly reduce the level of the stress response ingynecologic laparoscopic surgery.