Children With Whooping Cough And Asthma Capsule Asthma Model Guinea Pig Serum No, Mda And Sod Levels

Purpose: Bronchial asthma, eosinophils, mast cells and T lymphocytes and otherinflammatory cells and inflammatory factors involved in the chronic airway inflammatorydisease. A large number of studies show that inflammatory mediators involved in asthma havereached more than50kinds of IFN-γ, IL-4NO, MDA, and SOD in, the ET and otherindicators of the current research focus. This topic is to be adopted by the asthma model ofanimal experiments, observation of children with whooping cough capsules asthma model ofguinea pig serum inflammatory cytokines in NO, MDA and SOD levels of regulation, tryingto explain the molecular level children with whooping cough capsule in the anti-inflammatory,antioxidant, clear free radical aspects of the therapeutic effect of asthma in children, to furtherexplain the drug mechanism of action, pediatric asthma drug development to provideexperimental basis.Method: Guinea pigs were randomly divided into7groups (n=8), the blank controlgroup, model group, to aminophylline positive control group, cough Granules positive controlgroup, Xiaoer Xiaokechuan Capsules high dose group, dose group, low dose group. Modelgroup, positive control group, children with whooping cough high dose group, middle dosegroup, low dose group were injection of OVA aerosolized method to copy the model ofasthma. The blank control group with saline instead of intraperitoneal injection and aerosolinhalation. Each group were given the appropriate drugs. End of the experiment, testing eachgroup of guinea pig serum NO, MDA, and SOD. The test items whether there are differencesin each group of guinea pigs.Result: The asthma model of guinea pigs, SOD activity decreased NO, MDA levels.Xiaoer Xiaokechuan Capsules can significantly improve the activity of SOD and reduce serumNO, MDA level.Conclusion: Xiaoer Xiaokechuan Capsules have anti-inflammatory and free radicalscavenging, which may be its role in the healing of asthma.