| Objective:To study the correlation of vascular endothelial growth factor (VEGF)and colorectal liver metastases(CLM), by detecting the expression of VEGF in CLM and corresponding primary colorectal cancer to find the suitable patients of anti-VEGF targeted therapy.Methods:A total of 48 patients entered this study, including 22 cases who didn't appear liver metastases after adjuvant chemotherapy (including 5-fu±oxaliplatin at least 4 cycles),12 cases who appeared liver metastases after adjuvant chemotherapy, and 14 cases who with synchronous liver metastases at the diagnosis who underwent primary and metastases tissues resection. The expression of VEGF were evaluated immunohistochemically in the normal liver tissues, primary and metastases tissues. The relationship of VEGF expression and clinical pathological features and survival was Analyzed.Results:Positive expression rates of VEGF in colorectal cancer, liver metastases, normal liver tissue was 58.3%,64.2%,30.0%, no statistically significant difference were detected (P> 0.05). VEGF expression correlated with tumor stage, lymph node metastasis, liver metastases, preoperative CEA level (P< 0.05), and didn't correlate with gender, age, tumor type and classification, tumor size, liver metastases size (P> 0.05). In 48 cases, VEGF-positive-express in patients had lower DFS and OS than the VEGF negative ones (P< 0.05). In 34 cases who accepted adjuvant chemotherapy, VEGF-positive-expression patients had lower DFS and OS than VEGF negative ones (P < 0.05). Univariate analysis showed that age> 60, lymph node metastasis, preoperative CEA positive,ⅢorⅣstage, liver metastases, VEGF positive were prognostic factor, However, on multivariate analysis, only liver metastasis is the independent risk factors. Conclusion:Expression of VEGF correlates with tumor stage, lymph node,metastasis and preoperative serum CEA level. Indicating VEGF participates in the genesis and development of colorectal cancer, and could be regarded as an valuable index for predicting the prognosis. Patients with liver metastasis have higher VEGF positive rates than those without. We considere that liver metastasis is related with VEGF status. Liver metastasis is the independent risk factors and the expression of VEGF also can influence the DFS and OS, suggesting that VEGF may also be one of independent prognosis risk factors of colorectal cancer. Since VEGF expression correlates with the efficacy of adjuvant chemotherapy, we infer that patients with positive VEGF expression in primary colorectal cancer is considered to accept anti-VEGF targeted therapy. |
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