| Objectives:Guided by the basic theory of TCM, clinical use of nourish "Yin" soup third found carotid intima-media thickening of primary hypertension treatment, observation and to investigate the blood pressure, carotid intima-media thickness and other cardiovascular risk factors, nourish "Yin" soup for jahaziel to buck and carotid intima-media thickening of subsidise provide theoretical basis, role for the protection and endothelial, fight atherosclerosis looking for new effective method.Methods:From June 2010 to November 2010, choose between 60 cases for collecting has been diagnosed with primary hypertension, and confirmed by bilateral neck vascular color dopplar ultrasound examination of the carotid intima-media thickness increases, randomly divided into two groups, the observation group in the original western medicine, on the basis of oral treatment by TCM syndrome differentiation from liver and kidney, starting third, add with nourish "Yin" soup; The control group simple oral western medicine treatment, treatment 4 months. Monitoring before treating patients before and after the blood pressure level, check drug patients with carotid intima-media thickness and lipid (including TC/TG/LDL-C/HDL-C), blood sugar, blood uric acid, observing laboratory parameters such as the clinical symptoms of change. Income data to mean+sd (+s) said, using t-test, measurement data use X2 inspection, P< 0.05 has statistical significance, all statistics statistical software SPSS13.0 calculated by.Results:1.60 cases of essential hypertension with carotid intima-media thickening of patients, female patients with 32 cases, the total sample 53%,28 cases, men with total sample of 47 percent;< 60 patients in 12 cases,20% of the total sample, p 60 patients 48 cases and 80% of total samples. The X2 inspection, female patients with male patients difference was statistically significant, middle-aged and elderly patients with significant difference (P< 0.05), indicating that hypertension with carotid intima-media thickening in elderly patients with men and women primarily, but no obvious difference was sick.2. Effects on blood pressure:The observation group therapy before treatment low level after systolic blood pressure decreased obviously (P< 0.05), diastolic pressure before and after treatment (P> 0.05 no difference) before and after treatment, pulse pressure was significant difference (P< 0.05). The control group systolic blood pressure level compared with before treatment after treatment, a significant difference (P< 0.05), diastolic pressure before and after the treatment was significant difference (P< 0.05), pressing of arteries and veins before and after treatment (P> 0.05 no difference); Comparison between the two groups after treatment systolic blood pressure difference was statistically significant, and diastolic blood pressure and pulse pressure was significant difference (P<0.05). Explain combining traditional Chinese and western medicine treatment of western medicine therapy with simple systolic function is consistent, but the former have diastolic blood pressure is less than that of the latter, therefore influence of narrowing pulse pressure has obvious advantages.3. Influence for carotid intima-media thickness:Before and after the treatment the observation group carotid intima-media thickness decreases significantly (P<0.05), and the control group carotid intima-media thickness no significant difference (P>0.05). Nourish "Yin" soup that jahaziel carotid intima-media thickening have subsidise role.4. the influence of Blood sugar, blood fat and blood uric acid: Two groups within a group of patients with blood, blood sugar, blood compared before and after the treatment uric acid level:the observation group TC/HDL-C, blood sugar, blood uric acid level before and after the treatment was significant difference (P<0.05), TG/LDL-C level without difference (P>0.05). Control blood sugar, blood fat and blood uric acid level before and after the treatment without obvious difference (P>0.05). Comparison between the two groups after treatment TC/HDL-C, blood sugar and blood uric acid level has significant difference (P<0.05). Nourish "Yin" soup that has improved third hypertension in blood sugar, blood lipid levels, the role of serum uric acid level, especially in lower TC, blood sugar and blood uric acid, rise HDL-C, effect is obvious.5. Influence of clinical symptoms and signs:Two groups within a group of patients with clinical symptoms and signs comparison will be improved obviously (P<0.05), and the observation group powerfully cases significantly higher than that in control group (P< 0.05), invalid cases obviously lower than in control group (P < 0.05). Nourish "Yin" soup that jahaziel the role of the clinical symptoms improved better than pure oral western medicine group, the efficacy is outstanding.6. Safety testing:Two groups of patients the healing process are deelop aderse reactions and side effects, the security is high.Conclusion:This research shows that primary hypertension with carotid intima-media thickening in elderly patients. Nourish "Yin" soup third joint western medicine has significantly reduced systolic blood pressure, narrowing pulse pressure effect, and to carotid intima-media thickening have subsidise effect, also blood fat, blood sugar, blood uric acid level has obvious adjustment effect, still can obviously improve the clinical symptoms. Compared with the pure western medicine therapy, jahaziel to nourish "Yin" soup through many athersclerosis risk factors for the control effect, clinical step-down, softening vessels, protecting endothelial structural and functional treatment opened new ideas new methods. |
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