| Abstract:Guided by traditional Chinese medicine (TCM) theory, use the way of animal experimental study, to observe if the Jinkui Shenqi(金匮肾气)pill can improve the androgen levels and enhance sexual functiona on type 2 diabetic rats, and to explore its mechanism.Methods:40 SD male rats were divided into four groups randomly:normal control group,model group,positivecontrol group,Jinkui Shenqi pill treated group.The rats were injected in abdominal cavities with streptozotocin to makeType 2 diabetes model.Physiological saline was irrigated into the stomachs of the rats in the normal control group and model group,metformin and vigra were irrigated into the stomachs of the rats in the positivecontrol group,metformin and Jinkui Shenqi pill were irrigated into the stomachs of the rats in the Jinkui Shenqi pill treated group.After four weeks, fasting blood glucose,testosterone,nitric oxide were tested.Result:The GLU of Jinkui Shenqi pill treated group and positivecontrol group were significantly higher than model group (P (0.01), and has no difference with normal control group; the testosterone and nitric oxide of Jinkui Shenqi pill treated group and positivecontrol group were significantly higher than model group (P<0.05), and there is no difference between the two groups; the SHBG of positivecontrol group was significantly higher than normal control group(P <0.05),and there is no difference between the Jinkui Shenqi pill treated group and normal control group; Triglyceride after treatment of positivecontrol group was fallen significantly (P <0.05), and there is no difference between the positivecontrol group and normal control group; There is no difference between groups of cholesterol after treatment.Conclusion:The Jinkui Shenqi pill can effectively improve the androgen levels and enhance sexual functiona on type 2 diabetic rats, but no decrease of lipids,these show that the Jinkui Shenqi pill can effectively promote shenqi and do not effect dissolver of phlegmy wet. |
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