The Application Of TCT, HPV-DNA Testing, Visual Inspection In Primary Screening Of Cervical Cancer In Northern Guangdong

Objective: To evaluate the significance of HPV-DNA and TCT testing,visual inspection in primary screening of cervical cancer and its precancerous lesions in northern Guangdong's mountainous areas,to provide reference for cervical cancer prevention in northern Guangdong.Methods: All subjects came from Northern Guangdong. Collected the cervical exfoliated cells,and all cytological specimens were detected by TCT,HPV-DNA testing and visual inspection.Required for further colposcopy checking and histopathological examination. Preliminary analysis the prevalence in Northern Guangdong. All used SPSS13.0 to dealt with the data. Sensitivity,specificity,positive predictive value,negative predictive value,accuracy,youden's index were calculated. The statistical significance was assessed by chi-square test,P<0.05.Results: 1,This crowd participates in primary screening had no patient of Cervical Cancer,had one patient of CIN I,had two patients of CIN II,had five patients of CIN III. In this study,it's not statistically significant of the prevalence rate between Yao and Han women.2,The positive rates of TCT testing in primary screening was 10.39%,the number of ASCUS accounting for 7.79% of the total number. The infection rates of human papilloma virus was 14.72%.In this study,it's not statistically significant of the infection rates of human papilloma virus between Yao and Han women.The positive rates of visual inspection in primary screening was 14.72%.3,The infection rates of human papilloma virus and the positive rates of TCT and VIA,VILI increased gradually with the severity of cervical lesions.4,The sensitivity of TCT for detecting cervical cancer and its high Precancerous lesion was 87.5%,specificity 92.38%.The sensitivity of HPV was 75%,specificity 87.44%. The sensitivity of VIA and VILI was 62.5%,specificity 87%.The sensitivity and the specificity of TCT was higher than HPV,and the sensitivity and the specificity of HPV was higher than VIA and VILI.Conclusion: 1,In this study, the prevalence rate of cervical cancer and its precancerous lesions in Northern Guangdong was 3.46%,it was not statistically significant between Yao and Han women.2,TCT testing had the highest sensibility and specificity,so it's a good method in primary screening of cervical cancer and its precancerous lesions.Human papilloma virus was the cause of cervical cancer,so it made sense for HPV-DNA testing.Though the sensibility and specificity of visual inspection was not as high as TCT testing,but it met a need in primary screening for the women lived in the place where was poor and backward.