The Monoamine Neurotransmitter Expression Of Plasma In Adult Dental Fear Patients

Objectives:Investigate and analyze epidemiological characteristics and influencing factors of Dental Fear to adult patients, and address the relations between monoamine transmitters and adult Dental Fear.Methodologies:This research consists of two parts:1. With randomly extracted data on 400 adult patients receiving tooth extraction services at Outpatient Surgery Department of Jinan Stomatology Hospital during Jan.2009 and Dec.2010, epidemiological characteristics and influencing factors of adult Dental Fear (DF) are investigated, and analyzed by Dental Anxiety Scale (DAS) and Dental Fear Scale (DFS).2. Utilizing double antigens sandwich ELISA, statistical analysis and comparisons are accomplished by sampling concentrations of plasma norepinephrine (NE) and 5-hydroxytryptamine (5-HT) on 21 light anxiety dental fear patients,25 intermediate-heavy anxiety patients, and 33 non-anxiety patients.Results:1.14.5% incidence of Dental Fear exists among adult patients receiving tooth extraction services. DAS scoring differences on the following factors reveals statistical significance (P<0.05):age, gender, education level, times and causes of service, presence of relatives or friends, service experiences, endurance to pain, relatives'tooth extraction experience, life experience, mental state, tensions incurred at watching or overhearing tooth extraction talks; statistical non-significance (P>0.05) exist on residence, character, and service timings. With respect to treatment stimulus, patient anxieties are most vulnerable to feeling drill, hearing drill, and feeling anesthetic needle, which are 19.5%,17.5%, and 16.3% respectively. In terms of somatic anxiety, muscle tenseness and breath rate increase are remarkable symptoms, which appear on 18.8% and 16.8% patients respectively.2. Concentration samples of plasma norepinephrine (NE) and 5-hydroxytryptamine (5-HT) reveals:No statistical difference of NE levels exists between light anxiety group and intermediate-heavy anxiety group (p>0.05), however, NE levels of light anxiety group and intermediate-heavy anxiety group are significantly higher than that of non-anxiety group (p<0.01).No significant statistical difference exists among the three groups in the 5-HT level (P>0.05).Conclusions:1-. This study founds a high incidence of DF among Extraction patients.DF is complex and changeable as a kind of psychological activities. Different research object and the use of the DF scale inconsistent leads to markedly different results. Most of the scale are prepared from foreign scholars.Different cultural backgrounds and cultural habits lead to the domestic patients'misunderstanding on the scales, which can lead to discrepancy of survey results.2-This research of DF comes from the Neurotransmitter. NE levels of light anxiety group and intermediate-heavy anxiety group are significantly higher than that of non-anxiety group (p<0.01). This research reveals DF patients'anxiety can lead to increased activity of noradrenaline (NA). It prompting that both DF patients and other categories of anxieties have a same biological basis. Detect plasma NE concentration can provide objective clinical biological indicators. A new method is provides for quantitative research on DF.