| Depression is a disease which is characterized by last depressedmood. With the fast living pace,the high pressure of competition,more unpredictable things, the rate of getting depressed is rising. The mechanism of depression is almost unknown, and thedominant view is it is related to the brain's monoamine transmitters.The view believes that the change of the brain's monoaminetransmitters can result in depression. Some learners believe that thedecline of 5-HT can lead to depression, the decreased 5-HT isresponsible for people's depressed mood, bad appetite, anxiety, fewwords and so on. Something that can increase 5-HT can curedepression. Lixuepin can exhaust 5-HT, thus it can lead todepression. Some TCA can hold back the re-taking in of 5-HT andcure it. Others believe that the decrease of NE can make depressionhappen and the medicine to increase NE can treat it. The relationshipbetween depression and DA is uncertain. Now, the treatment on depression mainly depends on drug, butthe western medicine to cure it has some negative effects and thepatients can not endure it. It is necessary to study and use a new drugwhich is very effective and has little bad effect. A lot of studies reveal that the effect of traditional medicalprescription is certain and side effect is little, so its future is bright.SGJYY is a Chinese traditional medical prescription which is basedon the prescription of Shugan powder and Xiaoyao powder.Traditional Chinese medicine believes that a person's affection canaffect the liver's function and lead to the illness. This prescriptionmay relieve the liver pen, safeguard stomach against damages andsoothe the nerve and so on.The purpose of this experiment is to observe the effect ofSGJYY on monoamine transmitters and their metabolities in thebrain of depressed mice and the change in activity. After the model isbuilt up, compared with the normal group, the model group's lonlyfeeding and the chronic moderate intensive unpredictable stimulation, vertical score of open-field and sugar consumption descend and thetime of no-scaping ascends. The depressed mice are inactive and lesscurious to new surroundings. And they have little interests and aredespaired in bad environment. The different dosage of SGJYYgroups can improve the behavior of the depression mice to normallevel .We use HPLC-ECD to measure the monoamine transmittersand their metabolities. The result is 5-HT, NE, DA and DOPACreduce and 5-HIAA,MHPG go up. The big, medium, and smalldosages of SGJYY groups can lead to 5-HT, NE, DA, DOPACmount up and 5-HIAA and MHPG go down, thus they may berelated to reduce the metabolization of them. Some patients havephysical symptoms and we can further study the mechanism inmodern medicine. The prescription has the function such as: (1)calmness: Danshen restrains centrun nerve neural, and Suanzaorenhas the function of hypnosis which can improve the sick's insomniato various extents. (2) accelerate assimilation: the haw can enhancethe exudation of stomach enzyme. Yujin can accelerate the exudationand drainage of bile and this can improve the patient's symptom ofinappetence and dyspepsia. (3) protect liver: Chaihu can resist thedamnification of liver. Danggui and Baishao can promote the rebirthof liver cell. (4) regulate the immunity system: Chuangxiong andBaishao can adjust a rat's immunity response. Danshen can build upimmunity and resist cancer. Moreover, the powder can expandcoronary artery and enhance the blood of heart tiny circulation andplay down blood grease .So we can conclude that the mechanism ofSGJYY is that on one hand it can reduce the metobilization ofbrain's monoamine transmitters and it can exert the process ofimprove rest, promote appetite, protect liver, enhance immunity,meliorate tiny circulation, lower blood grease on the other hand.Thus it can deal with the physical symptoms of the sick.SGJYY has charmed away a great deal of depressed patients inclinic satisfactorily, and the result of this experiment shows that onthe point of view of animal experiment that it can reduce themetabolization of 5-HT,NE and enhance the content of 5-HT,NE inclearance to cure depression and improve the mice's behavior.This prescription using Traditional Chinese medicine theoryadjusts the function of every organism and the depressed symptomvanishes. So it can reach the aim of controlling a disease from itsroot The western medicine has the shortcoming of having many sideeffects and high price. The powder's curative effect is certain andside effect is little so it is ideal to therapy depression. The detrusionof it makes a new way to treat blue and deserves a wide applications. |
PDF Full Text Request