Yiwei Early Old Female Rats With Chronic Fatigue Syndrome Model Animal Metabolism Of Neurotransmitters Affect Experimental Research

Objects:This topic inherited a tradition term yiweitang ("WenBingTiaoBian") and applies drugs,which benefits fluid of YangMing and supplements qi of TaiYing,through the metabolism content influence of climacteric female rat chronic fatigue syndrome model animal central nervous system hands over,explore the occurrence mechanism of Chronic Fatigue Syndrome in premenopause;Offer a new treat pathway and security medicine for preventing and curing chronic fatigue syndrome in premenopause and improve women quality of life,and has proved the significance of traditional classic theory.Methods:Choose 10~12 months old SD female rat , climacteric female rat model was made by observing vaginal keratinized cell through papanicolaou staining for 4 estrous cycle,choose the rat whose oestrus elongation as climacteric female rat model. Experimental animal was devidede into 7 groups stochastically:1.normal blank group; 2.blank control group;3.yiweitang group in high dosage;4.yiweitang group in middledosage;5.yiweitang group in low dosage;6.yiweitang ChunQu group;7.Fluoxetine tablets group.4 weeks later after making the model and using herbs, executes climacteric female rat,takes the brain, rapidly sets in Specimen Jar with 4% paraformaldehyde,liquid 5 times to the specimen,the examination targets: NE,DA,5-HT,β-EP,MAO were measured.Results:Comparing with blank control group,in ordinary circumstances regulative aspect:Chinese traditional medicine yiweitang with benefiting fluid of YangMing and supplementing qi of TaiYing has the function of anti-weary,the enhancement study memory,the improvement inquisition behavior and the despondent mood;In the central nervous system hands over aspect:yiweitang decrease the MAO content through adjusting the single amines hand over the nature degeneration essential enzymes MAO content,enables NE and 5-HT content to have elevate;β-EP the content elevates,the DA content reduces,thus regulate central nervous system hands over the metabolism.Conclusions:Chinese traditional medicine yiweitang with benefiting fluid of YangMing and supplementing qi of TaiYing,possibly improves the metabolism of the central nervous system hands over,alleviate the condition of"chronic weary"the climacteric female rat body and psychological stress,promote the restoration of fatigue state.