Rat Central Nervous System And Autonomic Nervous System Activity Correlation Study

Autonomic nervous system (ANS) is a nerve device regulating entrails, which is originally controlled by central nervous system (CNS). Corresponding to the alteration of CNS status (e.g. sleep), the activity of ANS will be regulated to adapt the physiological status. But the quantitative relation of CNS activity and ANS activity is not confirmed, so we have done preliminary research on it to discover the mechanism of the regulation mechanism between CNS and ANS.In this paper, the 24h physiologic data of normal rats were recorded and heart rate variability (HRV) spectrum analysis and linear and non-linear analysis of EEG were carried out. Thus the activity of ANS and CNS were quantitated respectively, and the quantitative relation between the activity of CNS and the activity of ANS can be determined by: l.The trend of the activity of ANS and CNS over 24h; 2. The behavior of ANS during specific sleep stages; 3. Analyzing the correlation between the activity of CNS and ANS over 24h.The results demonstrates that, an obvious circadian rhythm exists in the activity of CNS and ANS; during sleep CNS is depressed while the vagal nerve system is excited, reciprocally during wake the vagal nerve is depressed while CNS is excited. The activity of ANS during different sleep stages is mainly represented by the fluctuation of the activity of sympathetic nerve system, while the vagal nerve system activity does not show any difference. During awake the sympathetic activity is most intensive and turns to be weak during SWS, and during REM the sympathetic activity will be enhanced again but the intensity is less than that during awake; By correlation analysis, it was found that the activity of CNS relates closely to the sympathovagal balance and the sympathetic activity, while there is a very weak correlation between the activity of CNS and vagal system.Thus we may infer the mechanism how CNS regulates ANS, and CNS mainly changes the sympathovagal balance to adapt the physiological status, which CNS roughly regulate vagal activity to adapt the overall physiological status, while the sympathetic activity is finely regulated to satisfy the real-time physiological need.